Abstract

The Iron Overload and Hereditary Hemochromatosis Study is an epidemiologic study of the prevalence, genetic and environmental determinants, and potential clinical, personal, and societal impact of iron overload and hereditary hemochromatosis in a multi-center, multi-ethnic, primary care-based sample of 100,000 adults. The information will be used to determine the feasibility and potential individual and public health benefits and risks of primary care-based screening and intervention for iron overload and hereditary hemochromatosis. The 100,000 participants will be recruited from five field centers for screening. Following the screening, a clinical examination will be conducted in selected individuals. The final component of the study is a family study which will use genome scanning and assessment of linkage to identify genetic variants related to the expression of iron overload and hereditary hemochromatosis disorders.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Epidemiology And Clinical Applications (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HC005190-001
Application #
6331068
Study Section
Project Start
2000-01-31
Project End
2005-01-31
Budget Start
2000-07-11
Budget End
2001-01-31
Support Year
Fiscal Year
2000
Total Cost
$7,603
Indirect Cost

  Institution

Name
University of California Irvine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Barton, James C; Barton, J Clayborn; Adams, Paul C et al. (2016) Risk Factors for Insulin Resistance, Metabolic Syndrome, and Diabetes in 248 HFE C282Y Homozygotes Identified by Population Screening in the HEIRS Study. Metab Syndr Relat Disord 14:94-101
Murray, Joseph A; McLachlan, Stela; Adams, Paul C et al. (2013) Association between celiac disease and iron deficiency in Caucasians, but not non-Caucasians. Clin Gastroenterol Hepatol 11:808-14
Gordeuk, Victor R; Lovato, Laura; Barton, James et al. (2012) Dietary iron intake and serum ferritin concentration in 213 patients homozygous for the HFEC282Y hemochromatosis mutation. Can J Gastroenterol 26:345-9
McLaren, Christine E; McLachlan, Stela; Garner, Chad P et al. (2012) Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations. PLoS One 7:e38339
Adams, Paul C; Speechley, Mark; Barton, James C et al. (2012) Probability of C282Y homozygosity decreases as liver transaminase activities increase in participants with hyperferritinemia in the hemochromatosis and iron overload screening study. Hepatology 55:1722-6
McLaren, Christine E; Garner, Chad P; Constantine, Clare C et al. (2011) Genome-wide association study identifies genetic loci associated with iron deficiency. PLoS One 6:e17390
McLaren, Christine E; Barton, James C; Eckfeldt, John H et al. (2010) Heritability of serum iron measures in the hemochromatosis and iron overload screening (HEIRS) family study. Am J Hematol 85:101-5
Adams, Paul; Barton, James C; McLaren, Gordon D et al. (2009) Screening for iron overload: lessons from the hemochromatosis and iron overload screening (HEIRS) study. Can J Gastroenterol 23:769-72
Speechley, Mark; Barton, James C; Passmore, Leah et al. (2009) Potential nonresponse bias in a clinical examination after initial screening using iron phenotyping and HFE genotyping in the hemochromatosis and iron overload screening study. Genet Test Mol Biomarkers 13:721-8
McLaren, Gordon D; Gordeuk, Victor R (2009) Hereditary hemochromatosis: insights from the Hemochromatosis and Iron Overload Screening (HEIRS) Study. Hematology Am Soc Hematol Educ Program :195-206

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