The primary objective of the Family and Genetic Studies of Cardiovascular Disease is to identify and evaluate genetic and nongenetic determinants of cardiovascular disease and its risk factors by: 1. developing and implementing standardized methods for ascertaining and validating family histories of cardiovascular disease and related conditions; 2. examining probands, spouses, and first degree relatives from affected families and probands, spouses, and first degree relatives from a random sample of families of participants in ongoing studies using standardized methods and criteria for diagnosing cardiovascular disease, measuring selected risk factors, and collecting, analyzing, and storing blood for studies of risk factors, genetic markers, and candidate genes; 3. comparing the distributions of genetic, behavioral, physical, biochemical, and environmental risk factors, and preclinical and overt disease in the two sets of families; and 4. identifying and estimating the contributions of the specific genetic and environmental determinants and their interactions to familial clustering, risk factors, and disease. The Coordinating Center will participant in the planning and conduct of this study. It will provide administrative and scientific leadership and coordination for the development of the final protocol. It will develop or modify a data base management system and will plan, implement, and maintain distributed data entry procedures for all data collection. The Coordinating Center will check, edit, store, and analyze study date and report the results.

Project Start
1992-05-01
Project End
1996-04-30
Budget Start
1992-05-01
Budget End
1995-04-30
Support Year
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Washington University
Department
Biostatistics & Other Math Sci
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Divers, Jasmin; Palmer, Nicholette D; Lu, Lingyi et al. (2013) Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus. Circ Cardiovasc Genet 6:97-105
Weatherley, Beth D; Chambless, Lloyd E; Heiss, Gerardo et al. (2006) The reliability of the ankle-brachial index in the Atherosclerosis Risk in Communities (ARIC) study and the NHLBI Family Heart Study (FHS). BMC Cardiovasc Disord 6:7
Pankow, James S; Heiss, Gerardo; Evans, Gregory W et al. (2004) Familial aggregation and genome-wide linkage analysis of carotid artery plaque: the NHLBI family heart study. Hum Hered 57:80-9
Djousse, Luc; Arnett, Donna K; Eckfeldt, John H et al. (2004) Alcohol consumption and metabolic syndrome: does the type of beverage matter? Obes Res 12:1375-85
Pankow, J S; Folsom, A R; Cushman, M et al. (2001) Familial and genetic determinants of systemic markers of inflammation: the NHLBI family heart study. Atherosclerosis 154:681-9
Tsai, M Y; Arnett, D K; Eckfeldt, J H et al. (2000) Plasma homocysteine and its association with carotid intimal-medial wall thickness and prevalent coronary heart disease: NHLBI Family Heart Study. Atherosclerosis 151:519-24
Borecki, I B; Province, M A; Ludwig, E H et al. (1997) Associations of candidate loci angiotensinogen and angiotensin-converting enzyme with severe hypertension: The NHLBI Family Heart Study. Ann Epidemiol 7:13-21
Ludwig, E H; Borecki, I B; Ellison, R C et al. (1997) Associations between candidate loci angiotensin-converting enzyme and angiotensinogen with coronary heart disease and myocardial infarction: the NHLBI Family Heart Study. Ann Epidemiol 7:3-12
Borecki, I B; Province, M A; Rao, D C (1994) Power of segregation analysis for detection of major gene effects on quantitative traits. Genet Epidemiol 11:409-18