The primary purpose of this project is to investigate risk factors for coronary heart disease (CHD) and stroke in the elderly. Risk factors for the development and progression of cardiovascular diseases will be examined in an elderly cohort. Risk factors for development of overt cardiovascular disease in an older population with prevalent atherosclerosis may differ from those related to the development of atherosclerosis in a younger population. The primary objective of the Echocardiography Reading Center (ERC) is to develop. implement, and monitor performance of a protocol for the echocardiographic examinations within the elderly study. The purpose of this examination is to quantify cardiac structure and function as related to risk of overt cardiovascular disease in an older population. In addition, certain echocardiographic parameters, such as LV mass, ejection fraction, valvular dysfunction, and wall motion abnormalities, may be used as secondary endpoints with which other risk factors will be correlated. The secondary objectives of the ERC are to: 1) develop methodology for rapid and reproducible measurement of echocardiographic studies performed at distant sites; and 2) standardize performance and maintain quality of echocardiographic examinations performed at multiple sites. The contractor shall serve as the Echocardiography Reading Center for this study. Duties of the ERC include equipment selection, protocol development, technician training, central reading, and data transmittal and analysis for the echocardiographic examinations within the elderly study.

Project Start
1988-06-01
Project End
1994-06-30
Budget Start
1991-07-01
Budget End
1992-06-30
Support Year
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Armstrong, Nicole M; Carlson, Michelle C; Schrack, Jennifer et al. (2018) Late-Life Depressive Symptoms as Partial Mediators in the Associations between Subclinical Cardiovascular Disease with Onset of Mild Cognitive Impairment and Dementia. Am J Geriatr Psychiatry 26:559-568
Kulminski, Alexander M; Huang, Jian; Loika, Yury et al. (2018) Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes. Aging (Albany NY) 10:492-514
Kamel, Hooman; Bartz, Traci M; Elkind, Mitchell S V et al. (2018) Atrial Cardiopathy and the Risk of Ischemic Stroke in the CHS (Cardiovascular Health Study). Stroke 49:980-986
Hammond, Christa A; Blades, Natalie J; Chaudhry, Sarwat I et al. (2018) Long-Term Cognitive Decline After Newly Diagnosed Heart Failure: Longitudinal Analysis in the CHS (Cardiovascular Health Study). Circ Heart Fail 11:e004476
Wild, Philipp S; Felix, Janine F; Schillert, Arne et al. (2017) Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. J Clin Invest 127:1798-1812
Garimella, Pranav S; Bartz, Traci M; Ix, Joachim H et al. (2017) Urinary Uromodulin and Risk of Urinary Tract Infections: The Cardiovascular Health Study. Am J Kidney Dis 69:744-751
Zillikens, M Carola; Demissie, Serkalem; Hsu, Yi-Hsiang et al. (2017) Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nat Commun 8:80
Lam, Max; Trampush, Joey W; Yu, Jin et al. (2017) Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets. Cell Rep 21:2597-2613
Wang, Heming; Choi, Yoonha; Tayo, Bamidele et al. (2017) Genome-wide survey in African Americans demonstrates potential epistasis of fitness in the human genome. Genet Epidemiol 41:122-135
Garg, Parveen K; Koh, Willam J H; Delaney, Joseph A et al. (2016) Risk Factors for Incident Carotid Artery Revascularization among Older Adults: The Cardiovascular Health Study. Cerebrovasc Dis Extra 6:129-139

Showing the most recent 10 out of 409 publications