Abstract

Primary objective is to measure the effect of use of combined oral contraceptive (COC) or depomedoxyprogesterone acetate (DMPA) on the acquisition of HIV infection. Secondary objectives are to: determinme if HIV seroconversion rates are modified by the presence or duration of other sexually transmitted diseases differently in users of COCs, DMPA, or no hormones, and examine the effect orf COCs or DMPA on factors which have been shown to influence HIV transmission, such as bacterial vaginosis, herpes simplex or human papillomavirus infection, genital HIV shedding, and viral fitness of non-clade B HIV. This study was established through intraagency agreement in FY 1997; the sole source contract for continuation of this study by NICHD was negotiated in Fy2000, to continue through FY2004.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research and Development Contracts (N01)
Project #
N01HD003310-000
Application #
6369522
Study Section
Project Start
2000-09-30
Project End
2004-09-29
Budget Start
2000-09-30
Budget End
2001-11-15
Support Year
Fiscal Year
2000
Total Cost
$6,873,144
Indirect Cost

  Institution

Name
Family Health International
Department
Type
DUNS #
067180786
City
Research Triangle Park
State
NC
Country
United States
Zip Code
27713

  Publications

Lemonovich, Tracy L; Watkins, Richard R; Morrison, Charles S et al. (2015) Differences in Clinical Manifestations of Acute and Early HIV-1 Infection between HIV-1 Subtypes in African Women. J Int Assoc Provid AIDS Care 14:415-22
Lancaster, Kathryn E; Kwok, Cynthia; Rinaldi, Anne et al. (2015) Incident pregnancy and pregnancy outcomes among HIV-infected women in Uganda and Zimbabwe. Int J Gynaecol Obstet 131:255-9
van de Wijgert, Janneke H H M; Verwijs, Marijn C; Turner, Abigail Norris et al. (2013) Hormonal contraception decreases bacterial vaginosis but oral contraception may increase candidiasis: implications for HIV transmission. AIDS 27:2141-53
Laeyendecker, Oliver; Kulich, Michal; Donnell, Deborah et al. (2013) Development of methods for cross-sectional HIV incidence estimation in a large, community randomized trial. PLoS One 8:e78818
Bengtson, Angela; Kwok, Cynthia; Salata, Robert A et al. (2013) Hormonal contraceptive use and discontinuation among HIV-infected women in Uganda and Zimbabwe. J Acquir Immune Defic Syndr 63:506-13
Morrison, Charles S; Chen, Pai-Lien; Nankya, Immaculate et al. (2011) Hormonal contraceptive use and HIV disease progression among women in Uganda and Zimbabwe. J Acquir Immune Defic Syndr 57:157-64
Nanda, Kavita; Morrison, Charles S; Kwok, Cynthia et al. (2011) Discontinuation of oral contraceptives and depot medroxyprogesterone acetate among women with and without HIV in Uganda, Zimbabwe and Thailand. Contraception 83:542-8
Taha, Taha E; James, Maria M; Hoover, Donald R et al. (2011) Association of recent HIV infection and in-utero HIV-1 transmission. AIDS 25:1357-64
Nowak, Rebecca G; Gravitt, Patti E; Morrison, Charles S et al. (2011) Increases in human papillomavirus detection during early HIV infection among women in Zimbabwe. J Infect Dis 203:1182-91
Bright, Patricia L; Norris Turner, Abigail; Morrison, Charles S et al. (2011) Hormonal contraception and area of cervical ectopy: a longitudinal assessment. Contraception 84:512-9

Showing the most recent 10 out of 35 publications