Abstract

The objective of this contract is to conduct a population-based case- control study to evaluate the relative and attributable risks of first episodes of fatal and non-fatal acute myocardial infarction (AMI) and stroke for users of oral contraceptives (OCs). Areas of interest include investigation of the risks among users of OC preparations containing less- than or equal-to 50ug estrogen, for those preparations containing the least estrogen and for the combined effects of smoking, age, and other risk factors for cardiovascular disease. The offeror proposes to make use of a case-ascertainment network including acute care hospitals, emergency medical services, physicians, paramedics and county medical examiners in King, Snohomish and Pierce Counties in Washington State. It is estimated that 150 cases of AMI, 175 cases of stroke and 580 controls will be identified over a 40-month data collection period.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research and Development Contracts (N01)
Project #
N01HD013107-004
Application #
2314556
Study Section
Project Start
1991-02-01
Project End
1995-08-31
Budget Start
1994-03-24
Budget End
1995-01-31
Support Year
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
Organized Research Units
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Lucas, Gavin; Lluís-Ganella, Carla; Subirana, Isaac et al. (2012) Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction. PLoS One 7:e41730
International Consortium for Blood Pressure Genome-Wide Association Studies (see original citation for additional authors) (2011) Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 478:103-9
Newton-Cheh, Christopher; Johnson, Toby; Gateva, Vesela et al. (2009) Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 41:666-76
Myocardial Infarction Genetics Consortium; Kathiresan, Sekar; Voight, Benjamin F et al. (2009) Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet 41:334-41
Kim, Helen; Friedlander, Yechiel; Longstreth Jr, W T et al. (2004) Family history as a risk factor for stroke in young women. Am J Prev Med 27:391-6
Longstreth Jr, W T; Rosendaal, F R; Siscovick, D S et al. (1998) Risk of stroke in young women and two prothrombotic mutations: factor V Leiden and prothrombin gene variant (G20210A) Stroke 29:577-80
Sidney, S; Siscovick, D S; Petitti, D B et al. (1998) Myocardial infarction and use of low-dose oral contraceptives: a pooled analysis of 2 US studies. Circulation 98:1058-63
Rosendaal, F R; Siscovick, D S; Schwartz, S M et al. (1997) A common prothrombin variant (20210 G to A) increases the risk of myocardial infarction in young women. Blood 90:1747-50
Rosendaal, F R; Siscovick, D S; Schwartz, S M et al. (1997) Factor V Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women. Blood 89:2817-21