The major objectives of this contract will be to (1) maintain a repository for the production, maintenance, and distribution of aneuploid mice with primary emphasis on trisomy 16 and (2) develop improved mouse models of chromosomal disorders, again with emphasis on trisomy 16. Two aspects of the project will be (1) to test which Robertsonian combinations are best for producing whole chromosome trisomies of specific chromosomes and (2) to induce translocations with small marker chromosomes containing segments of Chr. 16 and other selected chromosomes and demonstrate that adult mice with trisomy for small segments of the genome can be produced.

Project Start
1991-07-01
Project End
1996-06-30
Budget Start
1995-06-27
Budget End
1996-06-30
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
Davisson, M T; Schmidt, C; Reeves, R H et al. (1993) Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res 384:117-33