This procurement will produce a multiple arm observational study of women using various barrier contraceptive regimens for the prevention of the following sexually transmitted diseases (STDs): gonorrhoea and chlamydia. This study will determine the maximum possible protection against sexually transmitted diseases provided by consistent and correct use of barrier contraceptives. Secondary endpoints of interest will be the occurrence of other sexually transmitted diseases and pregnancy as detected during the study. The study design will include an educational and motivational component in order to assure an adequate number of participants with continued high levels of barrier use. Because of the personal nature of the decision to use a barrier method, the educational and motivational intervention will be aimed at all study participants, and subjects will choose which method (or no method) they will use during the follow-up period. A typical control group will not exist, the controls being intervention recruits who choose not to use a barrier method during the study. The study will determine: (1) the maximum extent to which various barrier contraceptive methods, used individually or in combination, can protect women from infection with Neisseria gonorrhoea and Chlamydia trachomatis; (2) evidence for the prevention of other STDs and pregnancy by consistent and proper barrier contraceptive use during the course of the study; (3) the correlates of failure (i.e. nonuse, improper use, condom breakage or slippage, other method failure); (4) local toxicity attributable to use of chemical or physical barrier contraceptive methods.

Project Start
1991-08-01
Project End
1995-01-31
Budget Start
1992-06-30
Budget End
1993-06-29
Support Year
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Penman-Aguilar, Ana; Macaluso, Maurizio; Peacock, Nadine et al. (2014) A novel approach to mixing qualitative and quantitative methods in HIV and STI prevention research. AIDS Educ Prev 26:95-108
Gallo, Maria F; Macaluso, Maurizio; Warner, Lee et al. (2012) Bacterial vaginosis, gonorrhea, and chlamydial infection among women attending a sexually transmitted disease clinic: a longitudinal analysis of possible causal links. Ann Epidemiol 22:213-20
Warner, Lee; Macaluso, Maurizio; Austin, Harland D et al. (2005) Application of the case-crossover design to reduce unmeasured confounding in studies of condom effectiveness. Am J Epidemiol 161:765-73
Artz, Lynn; Macaluso, Maurizio; Kelaghan, Joseph et al. (2005) An intervention to promote the female condom to sexually transmitted disease clinic patients. Behav Modif 29:318-69
Macaluso, Maurizio; Wang, Xingqiu; Brill, Ilene et al. (2005) Participation and retention in a study of female condom use among women at high STD risk. Ann Epidemiol 15:105-11
Posner, Samuel F; Pulley, Leavonne; Artz, Lynn et al. (2003) Use of psychometric techniques in the analysis of epidemiologic data. Ann Epidemiol 13:344-50
Macaluso, M; Demand, M; Artz, L et al. (2000) Female condom use among women at high risk of sexually transmitted disease. Fam Plann Perspect 32:138-44
Macaluso, M; Cheng, H; Akers, R (2000) Birth control method choice and use of barrier methods for sexually transmitted disease prevention among low-income African-American women. Contraception 62:13-May
Artz, L; Macaluso, M; Brill, I et al. (2000) Effectiveness of an intervention promoting the female condom to patients at sexually transmitted disease clinics. Am J Public Health 90:237-44
Macaluso, M; Demand, M J; Artz, L M et al. (2000) Partner type and condom use. AIDS 14:537-46

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