The objective of this contract program is to maintain and operate Synthetic Chemical Facility which is capable of rapidly synthesizing laboratory scale quantities (1-5 grams) of specific chemical compounds required for initial contraceptive investigation in small animals, providing relatively larger quantities (500 grams) of chemicals and/or drugs to the Contraceptive Development Branch for comprehensive anti-fertility testing, and providing chemical intermediates (1 kilogram) for other ongoing chemical contracts and other synthetic chemical efforts.
| Stratton, P; Hartog, B; Hajizadeh, N et al. (2000) A single mid-follicular dose of CDB-2914, a new antiprogestin, inhibits folliculogenesis and endometrial differentiation in normally cycling women. Hum Reprod 15:1092-9 |
| Rao, P N; Acosta, C K; Cessac, J W et al. (1999) Synthesis of N-desmethyl derivatives of 17alpha-acetoxy-11beta-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-die ne-3,20-dione and mifepristone1: substrates for the synthesis of radioligands. Steroids 64:205-12 |
| Rao, P N; Cessac, J W; Blye, R P et al. (1998) 11 beta-substituted 13 beta-ethyl gonane derivatives exhibit reversal of antiprogestational activity. Steroids 63:50-7 |
| Rao, P N; Cessac, J W; Kim, H K (1994) Preparative chemical methods for aromatization of 19-nor-delta 4-3-oxosteroids. Steroids 59:621-7 |
