The purpose of this service contract is to provide a facility for the storage, monitoring and distribution of the serum, plasma, and urine collected from the double-blind, randomized clinical trial of supplemental calcium for the prevention of preeclampsia (CPEP) during pregnancy from five clinical centers. It is expected during a two year period that 4,500 pregnant women will be enrolled in the study. Blood and urine specimens will be collected from study participants at baseline and early (26-29 weeks gestation) and late (26 weeks gestation) in the third trimester of pregnancy. Samples will also be collected at the time of diagnosis of preeclampsia and related conditions. Laboratory analyses will be performed at laboratories selected by the NICHD on the samples from selected study participants soon after the termination of pregnancy.
| Beste, Lauren A; England, Lucinda J; Schisterman, Enrique F et al. (2005) Pregnancy outcomes in smokers who develop pre-eclampsia. Paediatr Perinat Epidemiol 19:12-8 |
| Emery, Stephen P; Levine, Richard J; Qian, Cong et al. (2005) Twenty-four-hour urine insulin as a measure of hyperinsulinaemia/insulin resistance before onset of pre-eclampsia and gestational hypertension. BJOG 112:1479-85 |
| Levine, Richard J; Qian, Cong; Leshane, Erik S et al. (2004) Two-stage elevation of cell-free fetal DNA in maternal sera before onset of preeclampsia. Am J Obstet Gynecol 190:707-13 |
| England, Lucinda J; Levine, Richard J; Qian, Cong et al. (2004) Glucose tolerance and risk of gestational diabetes mellitus in nulliparous women who smoke during pregnancy. Am J Epidemiol 160:1205-13 |
| Saftlas, Audrey F; Levine, Richard J; Klebanoff, Mark A et al. (2003) Abortion, changed paternity, and risk of preeclampsia in nulliparous women. Am J Epidemiol 157:1108-14 |
| England, Lucinda J; Levine, Richard J; Qian, Cong et al. (2002) Smoking before pregnancy and risk of gestational hypertension and preeclampsia. Am J Obstet Gynecol 186:1035-40 |
| Stehman-Breen, Catherine O; Levine, Richard J; Qian, Cong et al. (2002) Increased risk of preeclampsia among nulliparous pregnant women with idiopathic hematuria. Am J Obstet Gynecol 187:703-8 |
| Regan, C L; Levine, R J; Baird, D D et al. (2001) No evidence for lipid peroxidation in severe preeclampsia. Am J Obstet Gynecol 185:572-8 |
| Morris, C D; Jacobson, S L; Anand, R et al. (2001) Nutrient intake and hypertensive disorders of pregnancy: Evidence from a large prospective cohort. Am J Obstet Gynecol 184:643-51 |
| Cohen, G R; Curet, L B; Levine, R J et al. (2001) Ethnicity, nutrition, and birth outcomes in nulliparous women. Am J Obstet Gynecol 185:660-7 |
