The goal of the proposed studies is to provide a formulation of C31G based agents into a vaginal contraceptive of high effectiveness together with the ability to: 1) provide rapid delivery of C31G after a single application, 2) provide long-acting spermicidal and microbicidal activity after a single application, 3) protect the user against AIDS (HIV) and other STDs, 4) protect vaginal and cervical epithelia from irritation, 5) enhance penetration of spermicide into cervical mucus, 6) demonstrate low systemic bioavailability and, finally 7) be pharmaceutically and cosmetically acceptable.

Project Start
1993-09-30
Project End
1996-09-29
Budget Start
1993-09-30
Budget End
1994-09-29
Support Year
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Thompson, K A; Malamud, D; Storey, B T (1996) Assessment of the anti-microbial agent C31G as a spermicide: comparison with nonoxynol-9. Contraception 53:313-8