Project Start
1984-09-30
Project End
1986-09-29
Budget Start
1985-05-01
Budget End
1986-09-29
Support Year
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
005436803
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Rivier, J E; Porter, J; Cervini, L A et al. (2000) Design of monocyclic (1-3) and dicyclic (1-3/4-10) gonadotropin releasing hormone (GnRH) antagonists. J Med Chem 43:797-806
Rivier, J E; Jiang, G; Struthers, R S et al. (2000) Design of potent dicyclic (1-5/4-10) gonadotropin releasing hormone (GnRH) antagonists. J Med Chem 43:807-18
Rivier, J E; Struthers, R S; Porter, J et al. (2000) Design of potent dicyclic (4-10/5-8) gonadotropin releasing hormone (GnRH) antagonists. J Med Chem 43:784-96
Struthers, R S; Tanaka, G; Koerber, S C et al. (1990) Design of biologically active, conformationally constrained GnRH antagonists. Proteins 8:295-304
Rivier, J; Kupryszewski, G; Varga, J et al. (1988) Design of potent cyclic gonadotropin releasing hormone antagonists. J Med Chem 31:677-82
Baniak 2nd, E L; Rivier, J E; Struthers, R S et al. (1987) Nuclear magnetic resonance analysis and conformational characterization of a cyclic decapeptide antagonist of gonadotropin-releasing hormone. Biochemistry 26:2642-56
Porter, J; Dykert, J; Rivier, J (1987) Synthesis, resolution and characterization of ring substituted phenylalanines and tryptophans. Int J Pept Protein Res 30:13-21
Mais, V; Kazer, R R; Cetel, N S et al. (1986) The dependency of folliculogenesis and corpus luteum function on pulsatile gonadotropin secretion in cycling women using a gonadotropin-releasing hormone antagonist as a probe. J Clin Endocrinol Metab 62:1250-5
Rivier, J E; Porter, J; Rivier, C L et al. (1986) New effective gonadotropin releasing hormone antagonists with minimal potency for histamine release in vitro. J Med Chem 29:1846-51