The objective of this contract program is to maintain and operate Synthetic Chemical Facility which is capable of rapidly synthesizing laboratory scale quantities (1-5 grams) of specific chemical compounds required for initial contraceptive investigation in small animals, providing relatively larger quantities (up to 1 Kg) of chemicals and/or drugs to the Contraceptive Development Branch for comprehensive anti- fertility testing, and providing chemical intermediates (1 Kg) for other ongoing chemical contracts and other synthetic chemical efforts.
| Attardi, Barbara J; Hild, Sheri A; Reel, Jerry R (2006) Dimethandrolone undecanoate: a new potent orally active androgen with progestational activity. Endocrinology 147:3016-26 |
| Rao, P N; Acosta, C K; Cessac, J W et al. (1999) Synthesis of N-desmethyl derivatives of 17alpha-acetoxy-11beta-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-die ne-3,20-dione and mifepristone1: substrates for the synthesis of radioligands. Steroids 64:205-12 |
