Abstract

The major objective of this contract will be to maintain a repository for the production, maintenance, and distribution of aneuploid mice with a primary emphasis on trisomy 16. In addition, special emphasis shall be made on the production and characterization of single gene transgenics and YAC or BAC transgenics utilizing segments of human chromosome 21. More specifically, the contractor will perform detailed phenotypic characterization of the Ts65Dn mouse and another partial trisomy, T232Dn while developing new transgenic mice carrying either single or multiple human chromosome 21 genes. All of the mice produced and those currently in the Repository shall be distributed to the research community.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research and Development Contracts (N01)
Project #
N01HD073265-003
Application #
2901514
Study Section
Project Start
1996-12-01
Project End
2001-11-30
Budget Start
1998-11-13
Budget End
1999-11-30
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609

  Publications

Spellman, Claire; Ahmed, Md Mahiuddin; Dubach, Daphne et al. (2013) Expression of trisomic proteins in Down syndrome model systems. Gene 512:219-25
Ahmed, Md Mahiuddin; Sturgeon, Xiaolu; Ellison, Misoo et al. (2012) Loss of correlations among proteins in brains of the Ts65Dn mouse model of down syndrome. J Proteome Res 11:1251-63
Costa, Alberto C S; Stasko, Melissa R; Schmidt, Cecilia et al. (2010) Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1). Behav Brain Res 206:52-62
Scott-McKean, Jonah Jacob; Chang, Bo; Hurd, Ronald E et al. (2010) The mouse model of Down syndrome Ts65Dn presents visual deficits as assessed by pattern visual evoked potentials. Invest Ophthalmol Vis Sci 51:3300-8
Han, Fengchan; Yu, Heping; Zhang, Jiangping et al. (2009) Otitis media in a mouse model for Down syndrome. Int J Exp Pathol 90:480-8
Reinholdt, Laura G; Czechanski, Anne; Kamdar, Sonya et al. (2009) Meiotic behavior of aneuploid chromatin in mouse models of Down syndrome. Chromosoma 118:723-36
Akeson, Ellen C; Donahue, Leah Rae; Beamer, Wesley G et al. (2006) Chromosomal inversion discovered in C3H/HeJ mice. Genomics 87:311-3
Davisson, M T; Bechtel, L J; Akeson, E C et al. (2001) Evolutionary breakpoints on human chromosome 21. Genomics 78:99-106