Abstract

The purpose of this acquisition is to apply the necessary tools to locate and identify the genes contributing to the inheritance of complex inheritance traits in humans. The contractor will implement and support databases for storage and retrieval of clinical, epidemiological, and genotype data implement new studies by developing questionnaires, contacting study subjects, obtaining necessary clearances, etc. acquire clinical and epidemiological data from selected families in which complex hereditary diseases are present and store data in electronic database. Acquire process and store biological specimens from individuals participating in research studies implement and apply methods for rapidly genotyping large numbers of individuals, implement and apply computer-based statistical methods to locate genes responsible for complex heritable traits in humans.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research and Development Contracts (N01)
Project #
N01HG065403-001
Application #
2606136
Study Section
Project Start
1996-09-23
Project End
2001-09-22
Budget Start
1997-07-07
Budget End
1998-06-30
Support Year
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Smith, Andrew H; Ovesen, Peter L; Skeldal, Sune et al. (2018) Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2. Alcohol Clin Exp Res 42:2337-2348
Liaqat, Khurram; Chiu, Ilene; Lee, Kwanghyuk et al. (2018) Novel missense and 3'-UTR splice site variants in LHFPL5 cause autosomal recessive nonsyndromic hearing impairment. J Hum Genet 63:1099-1107
Crist, R C; Doyle, G A; Nelson, E C et al. (2018) A polymorphism in the OPRM1 3'-untranslated region is associated with methadone efficacy in treating opioid dependence. Pharmacogenomics J 18:173-179
Agrawal, A; Chou, Y-L; Carey, C E et al. (2018) Genome-wide association study identifies a novel locus for cannabis dependence. Mol Psychiatry 23:1293-1302
Zhou, Hang; Cheng, Zhongshan; Bass, Nicholas et al. (2018) Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression. Transl Psychiatry 8:208
Cheng, Zhongshan; Zhou, Hang; Sherva, Richard et al. (2018) Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans. Biol Psychiatry 84:762-770
Zhang, Huiping; Zhou, Hang; Lencz, Todd et al. (2018) Genome-wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test. Am J Med Genet B Neuropsychiatr Genet 177:511-519
Scott, Robert A; Scott, Laura J; Mägi, Reedik et al. (2017) An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Diabetes 66:2888-2902
Polimanti, Renato; Zhao, Hongyu; Farrer, Lindsay A et al. (2017) Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors. Am J Med Genet B Neuropsychiatr Genet 174:846-853
Justice, Anne E (see original citation for additional authors) (2017) Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun 8:14977

Showing the most recent 10 out of 277 publications