To determine, in a population of 5-9 year old children with asthma, if regular use of either of two classes of anti-inflammatory medications (inhaled corticosteroids or cromolyn sodium), compared to regular bronchodilator medication and to each other, results in greater lung function and less bronchial hyperresponsiveness over a five year period. Secondary Objectives To determine if either of the anti-inflammatory medications, compared to bronchodilator medication and to each other, results in less patient morbidity, measured by frequency of asthma symptoms, days of limited activity, and days lost from school. To determine if either of the anti-inflammatory medications compared to regular bronchodilator medication and to each other results in less use of health care resources such as emergency room visits or hospitalizations. To compare the long term safety and side effects of the two classes of anti-inflammatory medications, compared to bronchodilator medication and to each other. To compare the effects of the two classes of anti-inflammatory medications, compared to bronchodilator medication and to each other, on physical and psychosocial development, and quality of life.
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| Park, Heung-Woo; Ge, Bing; Tse, Szeman et al. (2015) Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts. J Allergy Clin Immunol 136:1240-6.e1-8 |
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| Duan, Q L; Du, R; Lasky-Su, J et al. (2013) A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics. Pharmacogenomics J 13:130-6 |
| Schildcrout, Jonathan S; Garbett, Shawn P; Heagerty, Patrick J (2013) Outcome vector dependent sampling with longitudinal continuous response data: stratified sampling based on summary statistics. Biometrics 69:405-16 |
| Tse, Sze Man; Gold, Diane R; Sordillo, Joanne E et al. (2013) Diagnostic accuracy of the bronchodilator response in children. J Allergy Clin Immunol 132:554-559.e5 |
| Tse, Sze Man; Kelly, H William; Litonjua, Augusto A et al. (2012) Corticosteroid use and bone mineral accretion in children with asthma: effect modification by vitamin D. J Allergy Clin Immunol 130:53-60.e4 |
| Kelly, H William; Sternberg, Alice L; Lescher, Rachel et al. (2012) Effect of inhaled glucocorticoids in childhood on adult height. N Engl J Med 367:904-12 |
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