We propose to work within the context of 2 NIH-funded grants at our institutions to define abnormalities in cardiac and pulmonary function that occur in infants as young children with Human Immunodeficiency Virus infection. The importance of HIV itself will be determined by comparing the study group of infants with HIV infection with control groups of seronegative infants from either seropositive mothers or high risk, seronegative mothers. We will determine the extent of cardiopulmonary dysfunction in symptomatic infants by more invasive studies, institute appropriate therapy. The 2 ongoing grants are the Bay Area Perinatal AIDS Center and the Northern California Pediatric AIDS Treatment Center. The first project documents the natural history of maternal-infant pairs in which the mother is either seropositive for HIV or is seronegative but in a high risk group, and will be the source of our control patients. Infants who subsequently develop HIV infection will be enrolled in the second project, the Pediatric AIDS Treatment Center. These infants, along with other infants in the Treatment Center diagnosed with HIV infection but who were not enrolled in the Perinatal Center, will be the source of our study group. They undergo intensive immunologic, infectious, psychometric and neurologic evaluations on a quarterly basis, and we will coordinate its studies with the existing follow-up schedules whenever possible, so that the patients are not required to make additional visits.

Agency
National Institute of Health (NIH)
Institute
Division of Lung Diseases (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HR096039-000
Application #
3657667
Study Section
Project Start
1989-05-22
Project End
1990-06-15
Budget Start
1989-05-22
Budget End
1990-06-14
Support Year
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Fisher, Stacy D; Easley, Kirk A; Orav, E John et al. (2005) Mild dilated cardiomyopathy and increased left ventricular mass predict mortality: the prospective P2C2 HIV Multicenter Study. Am Heart J 150:439-47
Geromanos, Kimberly; Sunkle, Susan N; Mauer, Mary Beth et al. (2004) Successful techniques for retaining a cohort of infants and children born to HIV-infected women: the prospective P2C2 HIV study. J Assoc Nurses AIDS Care 15:48-57
Perez-Atayde, A R; Kearney, D I; Bricker, J T et al. (2004) Cardiac, aortic, and pulmonary arteriopathy in HIV-infected children: the Prospective P2C2 HIV Multicenter Study. Pediatr Dev Pathol 7:61-70
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Lipshultz, Steven E; Easley, Kirk A; Orav, E John et al. (2002) Cardiovascular status of infants and children of women infected with HIV-1 (P(2)C(2) HIV): a cohort study. Lancet 360:368-73
Starc, Thomas J; Lipshultz, Steven E; Easley, Kirk A et al. (2002) Incidence of cardiac abnormalities in children with human immunodeficiency virus infection: The prospective P2C2 HIV study. J Pediatr 141:327-34
Colin, A A; Sunil Rao, J; Chen, X C et al. (2001) Forced expiratory flow in uninfected infants and children born to HIV-infected mothers. Am J Respir Crit Care Med 163:865-73
Chinen, J; Easley, K A; Mendez, H et al. (2001) Decline of CD3-positive T-cell counts by 6 months of age is associated with rapid disease progression in HIV-1--infected infants. J Allergy Clin Immunol 108:265-8

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