Abstract

The primary objective of this multi-center project is to stimulate innovation in implantable ventricular assist systems that are designed to achieve at least a five-year lifetime. It is anticipated that the proposed systems will incorporate the latest advances in our understanding of circulatory support requirements, including physiology, materials science, physics and bioengineering, biocompatibility, tissue engineering, In situ tissue renewal, quality control, and manufacturing.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Heart And Vascular Diseases (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HV058155-000
Application #
2318064
Study Section
Project Start
1995-09-30
Project End
2000-09-29
Budget Start
1995-09-30
Budget End
1996-09-29
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Nimbus, Inc.
Department
Type
DUNS #
City
Rancho Cordova
State
CA
Country
United States
Zip Code
95670

  Publications

Fukamachi, Kiyotaka (2004) New technologies for mechanical circulatory support: current status and future prospects of CorAide and MagScrew technologies. J Artif Organs 7:45-57
Doi, Kazuyoshi; Golding, Leonard A R; Massiello, Alex L et al. (2004) Preclinical readiness testing of the Arrow International CorAide left ventricular assist system. Ann Thorac Surg 77:2103-10
Snyder, Trevor A; Watach, Mary J; Litwak, Kenneth N et al. (2002) Platelet activation, aggregation, and life span in calves implanted with axial flow ventricular assist devices. Ann Thorac Surg 73:1933-8
Fukamachi, Kiyotaka; Ochiai, Yoshie; Doi, Kazuyoshi et al. (2002) Chronic evaluation of the Cleveland Clinic CorAide left ventricular assist system in calves. Artif Organs 26:529-33
Ochiai, Yoshie; Golding, Leonard A R; Massiello, Alex L et al. (2002) Cleveland clinic CorAide blood pump circulatory support without anticoagulation. ASAIO J 48:249-52
Ochiai, Y; Golding, L A; Massiello, A L et al. (2001) In vivo hemodynamic performance of the Cleveland Clinic CorAide blood pump in calves. Ann Thorac Surg 72:747-52
Wagner, W R; Schaub, R D; Sorensen, E N et al. (2000) Blood biocompatibility analysis in the setting of ventricular assist devices. J Biomater Sci Polym Ed 11:1239-59
Butler, K C; Dow, J J; Litwak, P et al. (1999) Development of the Nimbus/University of Pittsburgh innovative ventricular assist system. Ann Thorac Surg 68:790-4
Baker, L C; Davis, W C; Autieri, J et al. (1998) Flow cytometric assays to detect platelet activation and aggregation in device-implanted calves. J Biomed Mater Res 41:312-21
Thomas, D C; Butler, K C; Taylor, L P et al. (1998) Progress on development of the Nimbus-University of Pittsburgh axial flow left ventricular assist system. ASAIO J 44:M521-4

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