The purpose of this program is to assess whether hormonal replacement therapy and/or antioxidant treatment will stabilize or inhibit progression, and induce regression of coronary plaques in women. Phase 1 (8 months) comprises planning and organizing the Study Protocols, Manual of Operations, and data forms. Protocol Development will take approximately 6 months. After Protocol Development, there will be an approximate 2 month hiatus in activity on the study. During this time, the participating centers will prepare and submit revised cost proposals based on the actual protocol. Phase 11(4 years) will be Thr patient recruitment and patient follow-up. Phase 111(6 months) is for data analysis.

Agency
National Institute of Health (NIH)
Institute
Division of Heart And Vascular Diseases (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HV068167-003
Application #
2802379
Study Section
Project Start
1996-08-30
Project End
2001-10-30
Budget Start
1998-05-20
Budget End
1999-04-30
Support Year
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Bittner, Vera; Tripputi, Mark; Hsia, Judith et al. (2004) Remnant-like lipoproteins, hormone therapy, and angiographic and clinical outcomes: the Women's Angiographic Vitamin & Estrogen Trial. Am Heart J 148:293-9
Hsia, Judith; Bittner, Vera; Tripputi, Mark et al. (2003) Metabolic syndrome and coronary angiographic disease progression: the Women's Angiographic Vitamin & Estrogen trial. Am Heart J 146:439-45
Hsia, Judith; Alderman, Edwin L; Verter, Joel I et al. (2002) Women's angiographic vitamin and estrogen trial: design and methods. Control Clin Trials 23:708-27