Treatment of Bipolar Disorder

Sachs, Gary S.

Abstract

A contract was signed in September, 1998, launching is a large, multicenter study sponsored by the National Institute of Mental Health (NIMH). Scheduled to begin in 1999, the study seeks to determine the most effective treatment strategies and to systematically assess outcomes of medication and psychosocial treatments for 5,000 - 10,000 patients with bipolar (manic-depressive) disorder. Data collected over a five year period will be analyzed to determine the impact of various treatments on specific outcomes, quality of life and illness-related costs. The Coordinating Center of the contract is at Massachusetts General Hospital in Boston. They are actively recruiting potential investigational sites to participate in this exciting longitudinal study, the largest such effort ever sponsored by the NIMH.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Mental Health (NIMH)
• Type: Research and Development Contracts (N01)
• Project #: N01MH080001-000
• Application #: 2884272
• Project Start: 1998-09-30
• Project End: 2003-09-30
• Budget Start: 1998-09-30
• Budget End: 1999-09-30
• Fiscal Year: 1998

Institution

• Name: Massachusetts General Hospital
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02199

Publications

Bareis, Natalie; Lu, Juan; Kirkwood, Cynthia K et al. (2018) Identifying clinical net benefit of psychotropic medication use with latent variable techniques: Evidence from Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). J Affect Disord 238:147-155

Mousavi, Zahra; Johnson, Sheri; Li, Descartes (2018) Does recent mania affect response to antidepressants in bipolar disorder? A re-analysis of STEP-BD data. J Affect Disord 236:136-139

Slyepchenko, A; Frey, B N; Lafer, B et al. (2017) Increased illness burden in women with comorbid bipolar and premenstrual dysphoric disorder: data from 1 099 women from STEP-BD study. Acta Psychiatr Scand 136:473-482

Sylvia, Louisa G; Salcedo, Stephanie; Peters, Amy T et al. (2017) Do Sleep Disturbances Predict or Moderate the Response to Psychotherapy in Bipolar Disorder? J Nerv Ment Dis 205:196-202

McCarthy, Shane; Das, Sayantan; Kretzschmar, Warren et al. (2016) A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet 48:1279-83

Fabbri, Chiara; Serretti, Alessandro (2016) Genetics of long-term treatment outcome in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 65:17-24

Stange, Jonathan P; Kleiman, Evan M; Sylvia, Louisa G et al. (2016) SPECIFIC MOOD SYMPTOMS CONFER RISK FOR SUBSEQUENT SUICIDAL IDEATION IN BIPOLAR DISORDER WITH AND WITHOUT SUICIDE ATTEMPT HISTORY: MULTI-WAVE DATA FROM STEP-BD. Depress Anxiety 33:464-72

Stange, Jonathan P; Sylvia, Louisa G; da Silva Magalhães, Pedro Vieira et al. (2016) Affective instability and the course of bipolar depression: results from the STEP-BD randomised controlled trial of psychosocial treatment. Br J Psychiatry 208:352-8

Ballard, Elizabeth D; Vande Voort, Jennifer L; Luckenbaugh, David A et al. (2016) Acute risk factors for suicide attempts and death: prospective findings from the STEP-BD study. Bipolar Disord 18:363-72

Bernstein, Emily E; Rabideau, Dustin J; Gigler, Margaret E et al. (2016) Patient perceptions of physical health and bipolar symptoms: The intersection of mental and physical health. J Affect Disord 189:203-6