Project Start
1984-04-16
Project End
1989-04-15
Budget Start
1987-09-25
Budget End
1989-03-31
Support Year
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
Schools of Pharmacy
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Gennings, C; Sofia, R D; Carchman, R A et al. (1995) Analysis of anticonvulsant and neurotoxic responses to combination therapy with carbamazepine, felbamate and phenytoin by response-surface modeling. Arzneimittelforschung 45:739-48
Johnson, D N; Osman, M A; Cheng, L K et al. (1990) Pharmacodynamics and pharmacokinetics of AHR-11748, a new antiepileptic agent, in rodents. Epilepsy Res 5:185-91
White, H S; Bender, A S; Swinyard, E A (1988) Effect of the selective N-methyl-D-aspartate receptor agonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid on [3H]flunitrazepam binding. Eur J Pharmacol 147:149-51
Swinyard, E A; Woodhead, J H; Franklin, M R et al. (1987) The effect of chronic felbamate administration on anticonvulsant activity and hepatic drug-metabolizing enzymes in mice and rats. Epilepsia 28:295-300
Swinyard, E A; Sofia, R D; Kupferberg, H J (1986) Comparative anticonvulsant activity and neurotoxicity of felbamate and four prototype antiepileptic drugs in mice and rats. Epilepsia 27:27-34
Ulloque, R A; Chweh, A Y; Swinyard, E A (1986) Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice. J Pharmacol Exp Ther 237:468-72
Lin-Michell, E; Chweh, A Y; Swinyard, E A (1986) Effect of ethosuximide alone and in combination with gamma-aminobutyric acid receptor agonists on brain gamma-aminobutyric acid concentration, anticonvulsant activity and neurotoxicity in mice. J Pharmacol Exp Ther 237:486-9
Chweh, A Y; Ulloque, R A; Swinyard, E A (1986) Benzodiazepine inhibition of [3H]flunitrazepam binding and caffeine-induced seizures in mice. Eur J Pharmacol 122:161-5
Chweh, A Y; Swinyard, E A; Wolf, H H (1986) Involvement of a GABAergic mechanism in the pharmacologic action of phenytoin. Pharmacol Biochem Behav 24:1301-4
Chweh, A Y; Swinyard, E A; Wolf, H H (1985) Benzodiazepine receptors are not involved in the neurotoxicity and anti-electroshock activity of phenytoin in mice. Neurosci Lett 57:279-82

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