The purpose of this contract project is for the development and validation of an animal model which can predict the development of tolerance to the anticonvulsant activity of three clinically used benzodiazepines.
Tietz, E I; Rosenberg, H C; Chiu, T H (1989) A comparison of the anticonvulsant effects of 1,4- and 1,5-benzodiazepines in the amygdala-kindled rat and their effects on motor function. Epilepsy Res 3:31-40 |