Abstract

The object is to evaluate the extent to which implanted neural tissues will repair injury to the contused spinal cord. Implants will be either cellular suspensions or whole segments of fetal cord. Mild and severe contusion models will be evaluated using morphological, physiological, and behavioral parameters for both types of implant. The extent of repair or connectivity between implants and host will be investigated with electron microscopy and electrophysiology. These findings will be correlated to observed functional status.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research and Development Contracts (N01)
Project #
N01NS072300-000
Application #
3670839
Study Section
Project Start
1987-09-28
Project End
1990-09-27
Budget Start
1987-09-28
Budget End
1988-09-27
Support Year
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Florida
Department
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611

  Publications

Thompson, F J; Reier, P J; Parmer, R et al. (1993) Inhibitory control of reflex excitability following contusion injury and neural tissue transplantation. Adv Neurol 59:175-84
Thompson, F J; Reier, P J; Lucas, C C et al. (1992) Altered patterns of reflex excitability subsequent to contusion injury of the rat spinal cord. J Neurophysiol 68:1473-86