Abstract

Data collection for a multicenter randomized controlled double blind clinical trial of barbiturate coma in intractable hypertension began on October 1, 1982. A study designed to derive a profile of the traumatic spinal cord injured patient began on January 1, 1983. Neuropsychological and psychosocial data is being collected on mildly head injured patients to study the cognitive impact and subsequent natural history of mild head injury in different populations. Studies being continued or completed include: an analysis of cognitive outcome of severe and moderate head injury; analysis to characterize demographic and clinical features; and studies of the features influencing outcome.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research and Development Contracts (N01)
Project #
N01NS092313-014
Application #
3671897
Study Section
Project Start
1979-09-30
Project End
1986-02-28
Budget Start
1985-09-30
Budget End
1986-02-28
Support Year
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine
Department
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Srivastava, Ajay K; White, H Steve (2013) Carbamazepine, but not valproate, displays pharmacoresistance in lamotrigine-resistant amygdala kindled rats. Epilepsy Res 104:26-34
Clausen, Rasmus P; Frolund, Bente; Larsson, Orla M et al. (2006) A novel selective gamma-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS. Neurochem Int 48:637-42
White, H Steve; Watson, William P; Hansen, Suzanne L et al. (2005) First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2. J Pharmacol Exp Ther 312:866-74
Schousboe, Arne; Larsson, Orla M; Sarup, Alan et al. (2004) Role of the betaine/GABA transporter (BGT-1/GAT2) for the control of epilepsy. Eur J Pharmacol 500:281-7
Schousboe, Arne; Sarup, Alan; Larsson, Orla M et al. (2004) GABA transporters as drug targets for modulation of GABAergic activity. Biochem Pharmacol 68:1557-63
White, H Steve; Sarup, Alan; Bolvig, Tina et al. (2002) Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkyla J Pharmacol Exp Ther 302:636-44
Isoherranen, Nina; White, H Steve; Finnell, Richard H et al. (2002) Anticonvulsant profile and teratogenicity of N-methyl-tetramethylcyclopropyl carboxamide: a new antiepileptic drug. Epilepsia 43:115-26
Barton, M E; Klein, B D; Wolf, H H et al. (2001) Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy. Epilepsy Res 47:217-27
Klauber, M R; Marshall, L F; Luerssen, T G et al. (1989) Determinants of head injury mortality: importance of the low risk patient. Neurosurgery 24:31-6
Marshall, L F; Knowlton, S; Garfin, S R et al. (1987) Deterioration following spinal cord injury. A multicenter study. J Neurosurg 66:400-4