Abstract

The major new objective is to conduct a collaborative, single-blind, randomized clinical trial evaluating the use of high-dose pentobarbital therapy for the control of elevated intracranial pressure in persons who have sustained significant and life threatening head injuries. If effective, significant reductions in head injury mortality and disability are expected. Continuing objectives include the evaluation of acute and rehabilitative care, research on neuropsychological consequences of mild head injury, improvement of community care for the spinal injured, and research on methods for the control and prevention of significant head/spinal injuries.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research and Development Contracts (N01)
Project #
N01NS092314-020
Application #
3671918
Study Section
Project Start
1979-09-01
Project End
Budget Start
1985-09-01
Budget End
1986-02-28
Support Year
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center Houston
Department
Type
Schools of Public Health
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225

  Publications

Farooqi, Nasr A I; Scotti, Martina; Lew, Ji Min et al. (2018) Role of DHEA and cortisol in prefrontal-amygdalar development and working memory. Psychoneuroendocrinology 98:86-94
Hamner, Taralee; Udhnani, Manisha D; Osipowicz, Karol Z et al. (2018) Pediatric Brain Development in Down Syndrome: A Field in Its Infancy. J Int Neuropsychol Soc 24:966-976
Lyle, Keith B; Dombroski, Brynn A; Faul, Leonard et al. (2017) Bimanual coordination positively predicts episodic memory: A combined behavioral and MRI investigation. Brain Cogn 118:71-79
Nguyen, Tuong-Vi; Wu, Mia; Lew, Jimin et al. (2017) Dehydroepiandrosterone impacts working memory by shaping cortico-hippocampal structural covariance during development. Psychoneuroendocrinology 86:110-121
Nguyen, Tuong-Vi; Lew, Jimin; Albaugh, Matthew D et al. (2017) Sex-specific associations of testosterone with prefrontal-hippocampal development and executive function. Psychoneuroendocrinology 76:206-217
Walker, Lindsay; Chang, Lin-Ching; Nayak, Amritha et al. (2016) The diffusion tensor imaging (DTI) component of the NIH MRI study of normal brain development (PedsDTI). Neuroimage 124:1125-30
Nguyen, Tuong-Vi; Gower, Patricia; Albaugh, Matthew D et al. (2016) The developmental relationship between DHEA and visual attention is mediated by structural plasticity of cortico-amygdalar networks. Psychoneuroendocrinology 70:122-33
Ekert, Kaspar; Groeschel, Samuel; Sánchez-Albisua, Iciar et al. (2016) Brain morphometry in Pontocerebellar Hypoplasia type 2. Orphanet J Rare Dis 11:100
Nguyen, Tuong-Vi; McCracken, James T; Albaugh, Matthew D et al. (2016) A testosterone-related structural brain phenotype predicts aggressive behavior from childhood to adulthood. Psychoneuroendocrinology 63:109-18
Ducharme, Simon; Albaugh, Matthew D; Nguyen, Tuong-Vi et al. (2016) Trajectories of cortical thickness maturation in normal brain development--The importance of quality control procedures. Neuroimage 125:267-279

Showing the most recent 10 out of 72 publications