This methodologic study will provide estimates of the accuracy of family history of cancer reports in a general population setting, which will help to evaluate the feasibility of future surveillance studies of genetic risk factors for cancer. A family history of cancer questionnaire will be developed and administered to a probability sample of approximately 1600 residents in the state of Connecticut. The questionnaire will ascertain the occurrence of cancer in the respondents' first and second degree relatives. Positive and negative reports of major cancers, including breast, prostate, lung, colorectal, and ovarian cancers, will be validated by searching state tumor registry records and other data sources (i.e., Medicare records, National Death Index files or death certificates, and physician reports)in order to determine the sensitivity and specificity of family history reports. Some additional epidemiologic and psychosocial variables will be collected to examine possible predictors of reporting accuracy and completeness.

Project Start
1999-09-30
Project End
2002-05-31
Budget Start
2000-10-25
Budget End
2001-09-29
Support Year
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Westat, Inc.
Department
Type
DUNS #
City
Rockville
State
MD
Country
United States
Zip Code
20850
Mai, Phuong L; Garceau, Anne O; Graubard, Barry I et al. (2011) Confirmation of family cancer history reported in a population-based survey. J Natl Cancer Inst 103:788-97
Wideroff, Louise; Garceau, Anne O; Greene, Mark H et al. (2010) Coherence and completeness of population-based family cancer reports. Cancer Epidemiol Biomarkers Prev 19:799-810
Mai, P L; Wideroff, L; Greene, M H et al. (2010) Prevalence of family history of breast, colorectal, prostate, and lung cancer in a population-based study. Public Health Genomics 13:495-503
Garceau, Anne; Wideroff, Louise; McNeel, Timothy et al. (2008) Population estimates of extended family structure and size. Community Genet 11:331-42