Abstract

The objectives of each Clinical Center are to cooperate with the Clinical Coordinating Center in implementing the overall Women's Health Initiative Clinical Trial and Observational Study. The Clinical Centers will join the sixteen Vanguard Clinical Centers in recruiting a group of postmenopausal U.S. women age 50-79, randomize them to a number of interventions, ensure adherence and adequate follow-up, and collect and transmit data and biological samples as needed for the ascertainment of the outcomes of the CT/OS. Each Clinical Center shall recruit 1,400 to the CT and 2,220 women to the OS.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Women'S Health Initiative - Office of The Director Nih (WH)
Type
Research and Development Contracts (N01)
Project #
N01WH042132-000
Application #
2326798
Study Section
Project Start
1994-09-30
Project End
2005-09-14
Budget Start
1994-09-30
Budget End
1997-06-22
Support Year
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Gong, J; Nishimura, K K; Fernandez-Rhodes, L et al. (2018) Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. Int J Obes (Lond) 42:384-390
Kato, Ikuko; Lane, Dorothy; Womack, Catherine R et al. (2017) Interaction between Nonsteroidal Anti-inflammatory Drugs and Low-fat Dietary Intervention on Colorectal Cancer Incidence; the Women's Health Initiative (WHI) Dietary Modification Trial. J Am Coll Nutr 36:462-469
Zaslavsky, Oleg; Woods, Nancy F; LaCroix, Andrea Z et al. (2016) Identification of Risk Factors for Mortality and Poor-Quality-of-Life Survival in Frail Older Women Participating in the Women's Health Initiative Observational Study. J Am Geriatr Soc 64:831-7
Ehret, Georg B (see original citation for additional authors) (2016) The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet 48:1171-1184
Klimentidis, Yann C; Bea, Jennifer W; Thompson, Patricia et al. (2016) Genetic Variant in ACVR2B Is Associated with Lean Mass. Med Sci Sports Exerc 48:1270-5
Smith, Caren E; Coltell, Oscar; Sorlí, Jose V et al. (2016) Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization. Sci Rep 6:33188
Klimentidis, Y C; Arora, A; Chougule, A et al. (2016) FTO association and interaction with time spent sitting. Int J Obes (Lond) 40:411-6
Siegel, Rebecca L; Jacobs, Eric J; Newton, Christina C et al. (2015) Deaths Due to Cigarette Smoking for 12 Smoking-Related Cancers in the United States. JAMA Intern Med 175:1574-6
Gangwisch, James E; Hale, Lauren; Garcia, Lorena et al. (2015) High glycemic index diet as a risk factor for depression: analyses from the Women's Health Initiative. Am J Clin Nutr 102:454-63
Salmoirago-Blotcher, Elena; Hovey, Kathleen M; Andrews, Christopher A et al. (2015) Statin use and risk of haemorrhagic stroke in a community-based cohort of postmenopausal women: an observational study from the Women's Health Initiative. BMJ Open 5:e007075

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