The woodchuck (Marmota monax) model infected with woodchuck-specific hepadnavirus (woodchuck hepatitis virus) has proven to be an important model to: Study pathogenesis (viral hepatitis, hepatocellular carcinoma); Assess efficacy and safety of antivirals for hepatitis B and D; Understand and target host responses to infection, protection, and viral resolution; and Study the comparative natural history of viral infections in woodchucks compared to humans.Testing in vivo may include obtaining samples of pharmacokinetic analysis, assessment of toxicity, dose escalation, immunostimulation, and efficacy of mono therapies and combinations of therapies.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
2008
Total Cost
$2,256,885
Indirect Cost
Name
Cornell University
Department
Type
DUNS #
872612445
City
Ithaca
State
NY
Country
United States
Zip Code
14850