Absorption, distribution, metabolism and elimination were begun on three ionic liquids that are promoted as replacements for halogenated solvents in degreasing applications. Oral and dermal studies are being conducted in support of the NTP sub-chronic toxicity studies. TBBPA and TBBPA-DBPE are used as flame retardents in circuit boards and polycarbonate-acrylonitrile-butadiene-styrene plastics. There is widespread worker exposure to these chemicals and possible consumer exposure. Special emphasis is being made to determine if TBBPA-DBPE is metabolized to produce 2,3-dibromopropyl ether, a known animal carcinogen. Present studies also include bioavailability studies of ionic liquids by the oral and dermal routes. Keywords Metabolite identification; NMR; HPLC; Mass spectrometry; Absorption; Distribution; Elimination; Kinetics; LSC; In vivo; In vitro; Radiolabeled compounds; Dermal; Gavage; IV; Inhalation; Mass balance; Ionic liquids; tetrabromobisphenol A; tetrabromobisphenol A-2,3 dibromopropyl ether; ionic liquids

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
2008
Total Cost
$664,334
Indirect Cost
Name
University of Arizona
Department
Type
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721