The primary objective of this SBIR Phase I contract is to focus on the medication development of puerarin (NPI-0311G), an isoflavonoid glycoside, as a potential therapeutic agent for attenuating alcohol drinking problems. The Contractor will: isolate in quantity puerarin from Kudzu and to establish a GLP quality control method; obtain the optimal doses of puerarin for suppressing alcohol intake in High Alcohol Drinking (HAD) rabbits; synthesize puerarin for preclinical pharmacokinetic studies; and generate preclinical data on toxicology, pharmacokinetics, disposition, and stability to support Phase II application and IND submission.

Project Start
1998-07-31
Project End
Budget Start
1998-10-14
Budget End
1999-01-29
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Natural Pharmacia International, Inc.
Department
Type
DUNS #
City
Burlington
State
MA
Country
United States
Zip Code
01803