For this program project we bring together a successful team of leading basic and clinical science experts to pursue research aimed at identifying novel therapeutics to address the recent surge in rates of alcohol use disorders (AUD) in women. Over the past 10 years, rates of AUD in women have increased by 84%, translating to 10.5 million women across the United States. Alcohol use is the third leading cause of preventable morbidity and mortality in the United States and women drinkers experience exacerbated health risks associated with alcohol consumption when compared to men. FDA-approved medications for AUD have low to moderate efficacy and none target factors that maintain drinking in women. A considerable body of data identifies that women are more likely to drink to regulate negative affect and stress, while men are more likely to drink for alcohol-related positive reinforcement. Across our three Projects, we will probe the noradrenergic system?s effects on stress reactivity and alcohol reinforcement. Our primary aim is to evaluate the role of the noradrenergic system to target sex-dependent factors known to maintain alcohol use in women versus men and to evaluate guanfacine as a prototypical medication to preferentially target these sex-dependent factors to improve AUD treatment outcomes.

Public Health Relevance

Rates of alcohol use disorders (AUD) in women have increased by 84% over the past 10 years. All FDA- approved medications for AUD have low to moderate efficacy and none target factors that maintain drinking in women. This research will contribute to the public health effort to improve AUD treatment, by providing a neurobiologically-informed approach to the development of sex-appropriate therapeutics for AUD, mentoring the next generation of interdisciplinary and translational researchers, and providing a national resource for women's health and alcohol use.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Program Projects (P01)
Project #
5P01AA027473-07
Application #
9794638
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Grakalic, Ivana
Project Start
2012-07-01
Project End
2020-08-31
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
7
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520