This project is aimed at using the SV40 large T antigen to elucidate the mechanism(s) of cellular senescence in WI-38 cells. We intend to use the ability of SV40 large T antigen to induce DNA synthesis in senescent WI- 38 cells to study 3 aspects of cellular senescence: 1) the expression of the PCNA gene; 2) the roles of B-myb, IGF-1 receptor; and 3) the immortalization of HDF by a ts mutuant of SV40 large T antigen.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
7P01AG000378-28
Application #
6200937
Study Section
Project Start
1999-09-01
Project End
2001-12-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
28
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Lankenau Institute for Medical Research
Department
Type
DUNS #
125797084
City
Wynnewood
State
PA
Country
United States
Zip Code
19096
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