Abstract

This program focuses on age changes in dopaminergic regulation in rodent models which are pertinent to idiopathic and drug-induced basal gangliar diseases of human aging. There are three interactive projects. (I) C.E. Finch. Characertization of dopaminergic receptor age changes by biochemical and endocrinological approaches to determine early events in agining. (II) P.K. Randall. Electrophysiological and behavioral characterization of dopaminergic receptor changes during aging. (III) D.S. Linthicum and M.B. Bolger. Development of immunologic probes (anti-idiotypic antibodies with dopaminergic specificities) which will be used to characterize dopamine receptor subtypes in projects I and II.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
3P01AG003272-03S1
Application #
3090671
Study Section
Aging Review Committee (AGE)
Project Start
1985-05-01
Project End
1985-12-31
Budget Start
1985-05-01
Budget End
1985-12-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
Organized Research Units
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90033

  Publications

Yurek, D M; Randall, P K (1991) Striatal depth EEG reveals postsynaptic activity of striatal neurons following dopamine receptor stimulation and blockade. J Neurosci Methods 37:81-91
Morgan, D G; Randall, J S; Telford, N A et al. (1987) Genotypic influences on pituitary responsiveness to haloperidol in mice. Psychoneuroendocrinology 12:211-8
Morgan, D G; Marcusson, J O; Nyberg, P et al. (1987) Divergent changes in D-1 and D-2 dopamine binding sites in human brain during aging. Neurobiol Aging 8:195-201
Severson, J A; Pittman, R N; Gal, J et al. (1986) Genetic influence on the regulation of beta adrenergic receptors in mice. J Pharmacol Exp Ther 236:24-9
Sherman, M A; Linthicum, D S; Bolger, M B (1986) Haloperidol binding to monoclonal antibodies: conformational analysis and relationships to D-2 receptor binding. Mol Pharmacol 29:589-98
Morgan, D G; Finch, C E (1986) [3H]Fluphenazine binding to brain membranes: simultaneous measurement of D-1 and D-2 receptor sites. J Neurochem 46:1623-31
Hartgraves, S L; Randall, P K (1986) Dopamine agonist-induced stereotypic grooming and self-mutilation following striatal dopamine depletion. Psychopharmacology (Berl) 90:358-63
Randall, P K; Randall, J S (1986) Mouse strain differences in apomorphine-induced behavior: an empirical and methodological study. Behav Neurosci 100:85-92
Mandel, R J; Randall, P K (1985) Quantification of lesion-induced dopaminergic supersensitivity using the rotational model in the mouse. Brain Res 330:358-63
Severson, J A; Randall, P K (1985) D-2 dopamine receptors in aging mouse striatum: determination of high- and low-affinity agonist binding sites. J Pharmacol Exp Ther 233:361-8

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