Abstract

The Animal Core provides support and oversight of the animal welfare. The Core will do routine animals? health maintenance and pathological screening of all rats. The Core maintains a database of pathological? analysis of aged and young rats and mice used by the Projects. This database can then be accessed by all? Project leaders. In addition, the Animal Core will provide important health monitoring of all rodents,? especially those that show premature aging.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG004418-25
Application #
7646327
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
25
Fiscal Year
2008
Total Cost
$38,407
Indirect Cost

  Institution

Name
University of South Florida
Department
Type
DUNS #
069687242
City
Tampa
State
FL
Country
United States
Zip Code
33612

  Publications

Bickford, Paula C; Flowers, Antwoine; Grimmig, Bethany (2017) Aging leads to altered microglial function that reduces brain resiliency increasing vulnerability to neurodegenerative diseases. Exp Gerontol 94:4-8
Grimmig, Bethany; Kim, Seol-Hee; Nash, Kevin et al. (2017) Neuroprotective mechanisms of astaxanthin: a potential therapeutic role in preserving cognitive function in age and neurodegeneration. Geroscience 39:19-32
Tajiri, Naoki; Acosta, Sandra A; Shahaduzzaman, Md et al. (2014) Intravenous transplants of human adipose-derived stem cell protect the brain from traumatic brain injury-induced neurodegeneration and motor and cognitive impairments: cell graft biodistribution and soluble factors in young and aged rats. J Neurosci 34:313-26
Lee, Daniel C; Ruiz, Claudia R; Lebson, Lori et al. (2013) Aging enhances classical activation but mitigates alternative activation in the central nervous system. Neurobiol Aging 34:1610-20
Lee, D C; Rizer, J; Hunt, J B et al. (2013) Review: experimental manipulations of microglia in mouse models of Alzheimer's pathology: activation reduces amyloid but hastens tau pathology. Neuropathol Appl Neurobiol 39:69-85
Ross, Jaime M; Stewart, James B; Hagström, Erik et al. (2013) Germline mitochondrial DNA mutations aggravate ageing and can impair brain development. Nature 501:412-5
Shahaduzzaman, Md; Golden, Jason E; Green, Suzanne et al. (2013) A single administration of human umbilical cord blood T cells produces long-lasting effects in the aging hippocampus. Age (Dordr) 35:2071-87
Olson, Linus; Faulkner, Stuart; Lundströmer, Karin et al. (2013) Comparison of three hypothermic target temperatures for the treatment of hypoxic ischemia: mRNA level responses of eight genes in the piglet brain. Transl Stroke Res 4:248-57
Morganti, Josh M; Nash, Kevin R; Grimmig, Bethany A et al. (2012) The soluble isoform of CX3CL1 is necessary for neuroprotection in a mouse model of Parkinson's disease. J Neurosci 32:14592-601
Li, Qingyou; Lebson, Lori; Lee, Daniel C et al. (2012) Chronological age impacts immunotherapy and monocyte uptake independent of amyloid load. J Neuroimmune Pharmacol 7:202-14

Showing the most recent 10 out of 317 publications