The Metabolic and Cardiac Effects of exercise in the Elderly Project represents the collaborative efforts of several Departments and Schools at the University of Washington to conduct a broad-based research program to define the metabolic and cardiovascular consequences of aerobic exercise training in the elderly with the hypothesis that training in the elderly will have a positive impact on the physiological parameters we have defined. The program project includes a core and four projects. The core will recruit and train the subjects, maintain and analyze the project data, oversee the implementation of the research activities, and promote relevant new research programs in areas related to the project. The four projects will address the following general issues in healthy young and elderly subjects: 1) The cardiovascular changes which occur with training and the adrenergic mechanisms which may be responsible for the adaptations that occur; 2) The effects of training on sympathetic nervous system activity, energy expenditure, and body composition; 3) The effects of training on adrenergic responsiveness as defined by adrenergic receptor function and adenylate cyclase activity; 4) The effects of training on carbohydrate metabolism and insulin sensitivity and release. The individual projects will be tied together not only by the Core activities but also by correlation of data between the different projects, e.g., the relationship between lymphocyte and platelet adrenergic receptor mechanisms and cardiovascular adrenergic responsiveness; the relationship between insulin sensitivity and both sympathetic activity, and body composition; and the correlation of adipose tissue adrenergic receptor mechanisms to body composition and fat distribution. We hypothesize that: 1) After participation in a 6 month aerobic exercise program both young and elderly subjects will demonstrate significant improvements in maximal aerobic capacity. 2) Improvements in other measured cardiovascular and metabolic parameters will occur in both young and elderly groups and will be proportional to the changes in aerobic capacity. Findings from these studies may ultimately help define the physiological and cellular responses to exercise training in the elderly. In the future it may be possible to restore lost responsiveness in aged target tissues by appropriate physiologic and biochemical manipulations.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG006581-03
Application #
3091094
Study Section
(GER)
Project Start
1987-02-01
Project End
1990-06-30
Budget Start
1989-02-01
Budget End
1990-06-30
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Stratton, J R (1999) Effects of age and gender on the cardiovascular responses to isoproterenol. J Gerontol A Biol Sci Med Sci 54:B401-3
Levy, W C; Cerqueira, M D; Harp, G D et al. (1998) Effect of endurance exercise training on heart rate variability at rest in healthy young and older men. Am J Cardiol 82:1236-41
Stratton, J R; Levy, W C; Cerqueira, M D et al. (1994) Cardiovascular responses to exercise. Effects of aging and exercise training in healthy men. Circulation 89:1648-55
Stratton, J R; Levy, W C; Schwartz, R S et al. (1994) Beta-adrenergic effects on left ventricular filling: influence of aging and exercise training. J Appl Physiol 77:2522-9
Chandler, W L; Levy, W C; Veith, R C et al. (1993) A kinetic model of the circulatory regulation of tissue plasminogen activator during exercise, epinephrine infusion, and endurance training. Blood 81:3293-302
Levy, W C; Cerqueira, M D; Abrass, I B et al. (1993) Endurance exercise training augments diastolic filling at rest and during exercise in healthy young and older men. Circulation 88:116-26
Levy, W C; Cerqueira, M D; Veith, R et al. (1992) Factors influencing serial measurements of cardiac volumes by count-based methods: effects of elevated catecholamines, position, and exercise on technetium-99m-blood radioactivity concentration. J Nucl Med 33:1324-9
Levy, W C; Jacobson, A F; Cerqueira, M D et al. (1992) Radionuclide cardiac volumes: effects of region of interest selection and correction for Compton scatter using a buildup factor. J Nucl Med 33:1642-7
Levy, W C; Cerqueira, M D; Matsuoka, D T et al. (1992) Four radionuclide methods for left ventricular volume determination: comparison of a manual and an automated technique. J Nucl Med 33:763-70
Schwartz, R S; Cain, K C; Shuman, W P et al. (1992) Effect of intensive endurance training on lipoprotein profiles in young and older men. Metabolism 41:649-54

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