New empirical findings in the biodemography of longevity have challenged the traditional models of mathematical demography on which the evolutionary theory of senescence and the demographic modeling of hazard functions have relied. This project seeks to deploy new advances in stochastic process theory, and where necessary extend them, to develop formal demographic models capable of accommodating patterns uncovered by biodemographic research.
Aim 1 is to construct stochastic demographic models for the dynamic generation and modification of hazard functions over evolutionary time which can successfully produce hazard functions that taper at extreme ages consistent with biodemographic observations.
Aim 2 is to derive individual-level consequences of aggregate hazard function models that generate heterogeneity implicitly and compare their testable consequences.
Aim 3 is to integrate models for resource constraints mediated through intergenerational transfers into mathematical formulations of evolutionary theories of senescence and revise and extend them. With an emphasis on testable consequences, this mathematical work seeks to synthesize findings from the other projects of the Program Project and prepare the way for effective use of future human data from sample surveys combining genetic and biological indicators with socio-demographic variables.
| Blackwell, Aaron D; Urlacher, Samuel S; Beheim, Bret et al. (2017) Growth references for Tsimane forager-horticulturalists of the Bolivian Amazon. Am J Phys Anthropol 162:441-461 |
| Ji, Hao; Müller, Hans-Georg; Papadopoulos, Nikos T et al. (2017) Quantifying functionals of age distributions in the wild by solving an operator equation. J Math Biol 75:973-984 |
| Garcia-Robledo, Carlos; Horvitz, Carol C; Kress, W John et al. (2017) Experimental assemblage of novel plant-herbivore interactions: ecological host shifts after 40 million years of isolation. Biotropica 49:803-810 |
| Gurven, Michael; Stieglitz, Jonathan; Trumble, Benjamin et al. (2017) The Tsimane Health and Life History Project: Integrating anthropology and biomedicine. Evol Anthropol 26:54-73 |
| Gurven, Michael D; Trumble, Benjamin C; Stieglitz, Jonathan et al. (2016) High resting metabolic rate among Amazonian forager-horticulturalists experiencing high pathogen burden. Am J Phys Anthropol 161:414-425 |
| Trumble, Benjamin C; Blackwell, Aaron D; Stieglitz, Jonathan et al. (2016) Associations between male testosterone and immune function in a pathogenically stressed forager-horticultural population. Am J Phys Anthropol 161:494-505 |
| Carey, James R; Liedo, Pablo; Xu, Cong et al. (2016) Diet Shapes Mortality Response to Trauma in Old Tephritid Fruit Flies. PLoS One 11:e0158468 |
| Krishna Kumar, Siddharth; Feldman, Marcus W; Rehkopf, David H et al. (2016) Limitations of GCTA as a solution to the missing heritability problem. Proc Natl Acad Sci U S A 113:E61-70 |
| Blackwell, Aaron D; Trumble, Benjamin C; Maldonado Suarez, Ivan et al. (2016) Immune function in Amazonian horticulturalists. Ann Hum Biol 43:382-96 |
| Blackwell, Aaron D; Tamayo, Marilyne A; Beheim, Bret et al. (2015) Helminth infection, fecundity, and age of first pregnancy in women. Science 350:970-2 |
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