Abstract

This is a program in medical mycology. Each of the research projects contained in the program is concerned with an important area of medical mycology and is directed by an expert in that area. Although the program is divided into separate projects, they are interrelated and strengthened by this interaction. In effect, this is a coordinated approach to the objective of improving the outcome of systemic fungal infections. The projects in the program involve the following: 1. The molecular biology of growth and phase transition of the dimorphic pathogenic fungus Histoplasma capsulatum. 2. Development of new sensitive and specific diagnostic methods which will allow earlier diagnosis of systemic fungal infections. 3. Host fungal interactions which involve the role of humoral and cell mediated immune responses to pathogenic fungi. 4. Development of new forms of chemotherapy and more efficient use of the older agents. 5. A coordinated effort using the participants in the program to teach a modern approach to medical mycology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI016228-09
Application #
3091468
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Project Start
1979-09-01
Project End
1989-08-31
Budget Start
1987-09-01
Budget End
1988-08-31
Support Year
9
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Lasker, B A; Page, L S; Lott, T J et al. (1992) Isolation, characterization, and sequencing of Candida albicans repetitive element 2. Gene 116:51-7
Lasker, B A; Page, L S; Lott, T J et al. (1991) Characterization of CARE-1: Candida albicans repetitive element-1. Gene 102:45-50
Wolf, J E; Stein, S H; Little, K D et al. (1991) Amphotericin B selectively stimulates macrophages from high responder mouse strains. Immunopharmacol Immunotoxicol 13:221-35
Brajtburg, J; Powderly, W G; Kobayashi, G S et al. (1990) Amphotericin B: current understanding of mechanisms of action. Antimicrob Agents Chemother 34:183-8
Jullien, S; Brajtburg, J; Bolard, J (1990) Affinity of amphotericin B for phosphatidylcholine vesicles as a determinant of the in vitro cellular toxicity of liposomal preparations. Biochim Biophys Acta 1021:39-45
Brajtburg, J; Powderly, W G; Kobayashi, G S et al. (1990) Amphotericin B: delivery systems. Antimicrob Agents Chemother 34:381-4
Spitzer, E D; Keath, E J; Travis, S J et al. (1990) Temperature-sensitive variants of Histoplasma capsulatum isolated from patients with acquired immunodeficiency syndrome. J Infect Dis 162:258-61
Harris, G S; Keath, E J; Medoff, J (1989) Expression of alpha- and beta-tubulin genes during dimorphic-phase transitions of Histoplasma capsulatum. Mol Cell Biol 9:2042-9
Maresca, B; Kobayashi, G S (1989) Dimorphism in Histoplasma capsulatum: a model for the study of cell differentiation in pathogenic fungi. Microbiol Rev 53:186-209
Keath, E J; Painter, A A; Kobayashi, G S et al. (1989) Variable expression of a yeast-phase-specific gene in Histoplasma capsulatum strains differing in thermotolerance and virulence. Infect Immun 57:1384-90

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