Abstract

We are performing a multidisciplinary investigation of basic and clinical aspects of fungal infection. Our project includes investigations to evaluate: molecular aspects of growth and morphogenesis in Mucorales and Candida albicans; mycotoxin production and susceptibility by pathogenic fungi, including the use of this phenomenon for biotyping fungal isolates; the prevalence and significance of fungal virus infection; new immunodiagnostic methods for the mycoses; and the contribution of phagocytic cells to host resistance to fungal infections.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI016252-10
Application #
3091474
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Project Start
1979-09-01
Project End
1989-08-31
Budget Start
1988-09-01
Budget End
1989-08-31
Support Year
10
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Rustchenko-Bulgac, E P; Howard, D H (1993) Multiple chromosomal and phenotypic changes in spontaneous mutants of Candida albicans. J Gen Microbiol 139 Pt 6:1195-207
Dabrowa, N; Zeuthen, M L; Howard, D H (1990) Nutritional stress proteins in Candida albicans. J Gen Microbiol 136:1387-91
Eisenhauer, P B; Harwig, S S; Szklarek, D et al. (1989) Purification and antimicrobial properties of three defensins from rat neutrophils. Infect Immun 57:2021-7
Wu-Hsieh, B; Howard, D H (1989) Macrophage cell lines P388D1 and IC-21 stimulated with gamma interferon fail to inhibit the intracellular growth of Histoplasma capsulatum. Infect Immun 57:2903-5
Zeuthen, M L; Howard, D H (1989) Thermotolerance and the heat-shock response in Candida albicans. J Gen Microbiol 135:2509-18
Lehrer, R I; Ganz, T; Szklarek, D et al. (1988) Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations. J Clin Invest 81:1829-35
Lehrer, R I; Barton, A; Ganz, T (1988) Concurrent assessment of inner and outer membrane permeabilization and bacteriolysis in E. coli by multiple-wavelength spectrophotometry. J Immunol Methods 108:153-8
Fleischmann, J; Howard, D H (1988) The DNA content of nongerminative variants of Candida albicans. Nucleic Acids Res 16:765
Lehrer, R I; Ganz, T; Selsted, M E (1988) Oxygen-independent bactericidal systems. Mechanisms and disorders. Hematol Oncol Clin North Am 2:159-69
Zeuthen, M L; Dabrowa, N; Aniebo, C M et al. (1988) Ethanol tolerance and the induction of stress proteins by ethanol in Candida albicans. J Gen Microbiol 134:1375-84

Showing the most recent 10 out of 45 publications