Abstract

This group of interlocking cooperative projects proposes to study the molecular mechanisms related to a number of devastating human conditions which have as their central feature an association with the human major histocompatibility complex. Both serologic, cellular, biochemical and molecular biological approaches will be used by a group of investigators to analyze at both the fundamental and clinical levels the role of HLA encoded gene products in the pathgenesis of various human diseases. Core facilities are requested in order to centralize resources and technology and to more efficiently utilize personnel and funds. Each of the individual projects follows directly from the laboratory to the clinic and back to the research laboratory and should provide important insights into the pathogenesis of human disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI023271-03
Application #
3091689
Study Section
(SRC)
Project Start
1986-07-01
Project End
1989-06-30
Budget Start
1988-07-01
Budget End
1989-06-30
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Texas Sw Medical Center Dallas
Department
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390

  Publications

Rani, R; Fernandez-Vina, M A; Zhang, S et al. (1995) HLA-DPB1 alleles in a population from north India and description of a new variant (DPB1*5601). Tissue Antigens 45:264-9
Satz, M L; Fernandez-Vina, M; Theiler, G C et al. (1995) Allelic heterogeneity of HLA-B35 subtypes in different populations as assessed by DNA typing. Tissue Antigens 46:196-203
Fernandez-Vina, M; Lazaro, A M; Sun, Y et al. (1995) Population diversity of B-locus alleles observed by high-resolution DNA typing. Tissue Antigens 45:153-68
Jackson, D G; Capra, J D (1995) TAP2 association with insulin-dependent diabetes mellitus is secondary to HLA-DQB1. Hum Immunol 43:57-65
Cerna, M; Vavrincova, P; Havelka, S et al. (1994) Class II alleles in juvenile arthritis in Czech children. J Rheumatol 21:159-64
Wilson, K B; Quayle, A J; Suleyman, S et al. (1993) Heterogeneity of the TCR repertoire in synovial fluid T lymphocytes responding to BCG in a patient with early rheumatoid arthritis. Scand J Immunol 38:102-12
Stastny, P; Fernandez-Vina, M; Cerna, M et al. (1993) Sequences of HLA alleles associated with arthritis in adults and children. J Rheumatol Suppl 37:5-8
Moraes, M E; Fernandez-Vina, M; Salatiel, I et al. (1993) HLA class II DNA typing in two Brazilian populations. Tissue Antigens 41:238-42
Fernandez-Vina, M; Ramirez, L C; Raskin, P et al. (1993) Genes for insulin-dependent diabetes mellitus (IDDM) in the major histocompatibility complex (MHC) of African-Americans. Tissue Antigens 41:57-64
Randen, I; Pascual, V; Victor, K et al. (1993) Synovial IgG rheumatoid factors show evidence of an antigen-driven immune response and a shift in the V gene repertoire compared to IgM rheumatoid factors. Eur J Immunol 23:1220-5

Showing the most recent 10 out of 38 publications