Abstract

This is a program project application for research in pelvic inflammatory disease (PID) and Chlamydial infection. The project includes a Core and three research projects: Specific chlamydia protein in PID sequelae; Consequences of PID; and Evaluation of therapeutic regimens for treatment of PID; Clinical response and microbiologic cure. The core brings together clinical facilities (Reproductive Infectious Diseases, SFGH; City Clinic, San Francisco; Adolescent Medicine, UCSF) clinically and epidemiologically oriented investigations on pelvic inflammatory disease, Chlamydia, N. gonorrhoeae infection, and other STD organisms, and the STD Training Program. In turn, these clinical and epidemiologic programs provide excellent opportunities for collaboration with basic science research activities of the Bay Area STD Research Program. The integration of these research resources provides an environment with an excellent balance between clinical and basic science investigation. East of the research projects will make use of the Core resources to enhance our understanding of pelvic inflammatory disease and chlamydial infection.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI024768-05
Application #
3091816
Study Section
Special Emphasis Panel (SRC (03))
Project Start
1987-06-01
Project End
1992-05-31
Budget Start
1991-06-01
Budget End
1992-05-31
Support Year
5
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Jossens, M O; Eskenazi, B; Schachter, J et al. (1996) Risk factors for pelvic inflammatory disease. A case control study. Sex Transm Dis 23:239-47
Jossens, M O; Schachter, J; Sweet, R L (1994) Risk factors associated with pelvic inflammatory disease of differing microbial etiologies. Obstet Gynecol 83:989-97
Summitt Jr, R L; Sipes 2nd, D R; Bent, A E et al. (1994) Evaluation of pressure transmission ratios in women with genuine stress incontinence and low urethral pressure: a comparative study. Obstet Gynecol 83:984-8
Washington, A E; Katz, P (1993) Ectopic pregnancy in the United States: economic consequences and payment source trends. Obstet Gynecol 81:287-92
Walker, C K; Kahn, J G; Washington, A E et al. (1993) Pelvic inflammatory disease: metaanalysis of antimicrobial regimen efficacy. J Infect Dis 168:969-78
Safrin, S; Schachter, J; Dahrouge, D et al. (1992) Long-term sequelae of acute pelvic inflammatory disease. A retrospective cohort study. Am J Obstet Gynecol 166:1300-5
Rice, P A; Schachter, J (1991) Pathogenesis of pelvic inflammatory disease. What are the questions? JAMA 266:2587-93
Washington, A E; Cates Jr, W; Wasserheit, J N (1991) Preventing pelvic inflammatory disease. JAMA 266:2574-80
Reed, S D; Landers, D V; Sweet, R L (1991) Antibiotic treatment of tuboovarian abscess: comparison of broad-spectrum beta-lactam agents versus clindamycin-containing regimens. Am J Obstet Gynecol 164:1556-61;discussion 1561-2
Washington, A E; Katz, P (1991) Cost of and payment source for pelvic inflammatory disease. Trends and projections, 1983 through 2000. JAMA 266:2565-9

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