The Administrative Core will provide the scientific leadership and organizational management to assure thatthe program project: 'Defining the Pathogenesis of immune deficiency in chronic HIV infection' meets itsobjectives effectively by:Developing an organizational structure that assures effective scientific leadership.Providing the fiscal and administrative management of the program, including grant reportingrequirements, accounting and sub-contracts that includes coordination of communications with NIH andwith industry collaborators and assuring seamless coordination of access to resources within theprogram to assure their timely and cost-efficient utilization to assist in project completion.Coordinating communication among all project investigators, project Cores and institutionaladministrations located at multiple institutions and among program external advisors. This will includeorganizing team meetings, conference calls and recording and distributing minutes of calls anddistribution of presentations.Maintaining a system to promote sharing of research output of the group that includes maintaining a website for Project documents, methods, manuscripts, publications, slide presentations and other keyinformation on program progress.Monitoring scientific productivity, assuring appropriate resource allocation and establishing a mechanismfor resolution of any conflicts should they arise.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
1P01AI076174-01A1
Application #
7525016
Study Section
Special Emphasis Panel (ZAI1-PRJ-A (J1))
Project Start
2008-08-01
Project End
2013-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
1
Fiscal Year
2008
Total Cost
$184,251
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Castillo-Mancilla, Jose R; Morrow, Mary; Boum, Yap et al. (2018) Brief Report: Higher ART Adherence Is Associated With Lower Systemic Inflammation in Treatment-Naive Ugandans Who Achieve Virologic Suppression. J Acquir Immune Defic Syndr 77:507-513
Carnathan, Diane; Lawson, Benton; Yu, Joana et al. (2018) Reduced Chronic Lymphocyte Activation following Interferon Alpha Blockade during the Acute Phase of Simian Immunodeficiency Virus Infection in Rhesus Macaques. J Virol 92:
Freeman, Michael L; Morris, Stephen R; Lederman, Michael M (2017) CD161 Expression on Mucosa-Associated Invariant T Cells is Reduced in HIV-Infected Subjects Undergoing Antiretroviral Therapy Who Do Not Recover CD4+ T Cells. Pathog Immun 2:335-351
Siewe, Basile; Nipper, Allison J; Sohn, Haewon et al. (2017) FcRL4 Expression Identifies a Pro-inflammatory B Cell Subset in Viremic HIV-Infected Subjects. Front Immunol 8:1339
McGinty, Tara; Mirmonsef, Paria; Mallon, Patrick W G et al. (2016) Does systemic inflammation and immune activation contribute to fracture risk in HIV? Curr Opin HIV AIDS 11:253-60
Siedner, Mark J; Kim, June-Ho; Nakku, Ruth Sentongo et al. (2016) HIV infection and arterial stiffness among older-adults taking antiretroviral therapy in rural Uganda. AIDS 30:667-70
Fu, P; Hughes, J; Zeng, G et al. (2016) A comparative investigation of methods for longitudinal data with limits of detection through a case study. Stat Methods Med Res 25:153-66
Luo, Zhenwu; Ma, Lei; Zhang, Lumin et al. (2016) Key differences in B cell activation patterns and immune correlates among treated HIV-infected patients versus healthy controls following influenza vaccination. Vaccine 34:1945-55
Shive, Carey L; Clagett, Brian; McCausland, Marie R et al. (2016) Inflammation Perturbs the IL-7 Axis, Promoting Senescence and Exhaustion that Broadly Characterize Immune Failure in Treated HIV Infection. J Acquir Immune Defic Syndr 71:483-92
Lee, Sulggi A; Mefford, Joel A; Huang, Yong et al. (2016) Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans. AIDS 30:1807-15

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