The Administration Core (Core A) will have primary responsibility for overall scientific and financial management of the P01. The overall mission of this P01 is to assemble a comprehensive program that integrates bioinformatic and genomic expertise to enable not only identification of disease-causing variants in individuals with SCID and T cell deficiencies, but also to exploit genome editing as a truly personalized approach to treatment. The P01will have three research Projects: Project 1,Systematic identification of candidate disease-causing variants in patients with T cell insufficiency; Project 2. Genome editing to create, validate and correct allelic variants responsible for T cell insufficiency; and Project 3, Functional analysis of allelic variants responsible for T cell insufficiency. These will be complemented by three Cores (including this one): Core A, Administration; Core B, Informatics Infrastructure and Bioinformatics Analysis; and Core C, Participant Enrollment and Sample Management. The Administration Core will meet its responsibility by implementing four specific aims: 1) Provide strong scientific leadership; 2) Provide administrative support; 3) Provide fiscal oversight and management of all P01 activities; and 4) Facilitate all planning and evaluation activities for the P01. This work will ensure effective progress, optimal utilization of resources, and enhancement of the synergies among P01 investigators and Projects. The Administration Core includes a Steering Committee consisting the Co-Principal Investigators and the Project and Core Leads, which will be responsible for reviewing progress and making major decisions, and will be based at the University of California, San Francisco (UCSF).
