Abstract

The program consists of four major areas: 1) Structural and functional studies of connective tissue, serum and membrane proteins including cartilage constituents and fibronectin. 2) Humoral immunity including the structure, function, biosynthesis and genetic control of immunoglobulins and factors involved in the regulation of antibody synthesis. In parallel and complementing this, there is an active program devoted to the structure of certain complement components and their interaction with cellular receptors. Clinically, these studies converge on patients with immune complex diseases and patients with lymphoproliferative or plasma cell disorders. 3) Cellular mechanisms in diseases. In particular there is a multidisciplinary collaborative effort to define subsets of monocytes, to study the role of surface enzymes in normal and disordered monocyte function, and to correlate the structure and function of various subsets of lymphocytes. These studies focus on the amyloid diseases and various lymphoid neoplasms. 4) Genetics, development and membrane structure. The main focus of this work is to evaluate the role of genetic factors in resistance to leukemia and to study various surface components of lymphoid cells coded by the major histocompatibility locus that behave as differentiation markers and may play a role in lymphocyte function and cell-cell interaction.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK)
Type
Research Program Projects (P01)
Project #
2P01AM001431-29
Application #
3092238
Study Section
(SRC)
Project Start
1976-01-01
Project End
1989-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
29
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Type
Schools of Medicine
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012

  Publications

Garcia-Pardo, A; Gold, L I (1993) Further characterization of the binding of fibronectin to gelatin reveals the presence of different binding interactions. Arch Biochem Biophys 304:181-8
Warfel, A H; Zucker-Franklin, D (1992) Specific ligation of surface alpha-D-galactosyl epitopes markedly affects the quantity of four major proteins secreted by macrophages. J Leukoc Biol 52:80-4
Zucker-Franklin, D; Coutavas, E E; Rush, M G et al. (1991) Detection of human T-lymphotropic virus-like particles in cultures of peripheral blood lymphocytes from patients with mycosis fungoides. Proc Natl Acad Sci U S A 88:7630-4
Warfel, A H; Zucker-Franklin, D; Zheng, Z Y (1991) Macrophage membrane glycoproteins that bind Griffonia simplicifolia I-B4: effect on cytotoxicity and protein secretion. J Cell Physiol 147:265-73
Warfel, A H; Cardozo, C; Yoo, O H et al. (1991) Cystatin C and cathepsin B production by alveolar macrophages from smokers and nonsmokers. J Leukoc Biol 49:41-7
Picken, M M; Gallo, G R; Pruzanski, W et al. (1990) Biochemical characterization of amyloid derived from the variable region of the kappa light chain subgroup III. Arthritis Rheum 33:880-4
Jacobson, D R; Gorevic, P D; Buxbaum, J N (1990) A homozygous transthyretin variant associated with senile systemic amyloidosis: evidence for a late-onset disease of genetic etiology. Am J Hum Genet 47:127-36
Zucker-Franklin, D; Cao, Y Z (1989) Megakaryocytes of human immunodeficiency virus-infected individuals express viral RNA. Proc Natl Acad Sci U S A 86:5595-9
Picken, M M; Frangione, B; Barlogie, B et al. (1989) Light chain deposition disease derived from the kappa I light chain subgroup. Biochemical characterization. Am J Pathol 134:749-54
Nabi, Z F; Zucker-Franklin, D; Baten, A (1989) Phorbol ester-induced loss of membrane sialic acid: implications for tumor cytolysis by natural killer cells. J Leukoc Biol 45:183-8

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