Abstract

Pathogenesis of calcium oxalate stones is under study. Serum PTH and 1,25(OH)2D3 and nephrogenous cyclic AMP are being measured along with response to low calcium diet and thiazide in patients with idiopathic hypercalciuria. Urine saturation and crystal growth inhibition are being measured in stone formers, in response to various forms of treatment. The factors that influence the ability of crystallization to occur on the surface of the urothelium, specifically the effects of urothelial injury on the deposition and attachment of calcium oxalate crystals, is being studied.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK)
Type
Research Program Projects (P01)
Project #
5P01AM033949-03
Application #
3092282
Study Section
(SRC)
Project Start
1983-09-01
Project End
1987-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Chicago
Department
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Tsuruoka, S; Bushinsky, D A; Schwartz, G J (1997) Defective renal calcium reabsorption in genetic hypercalciuric rats. Kidney Int 51:1540-7
Bushinsky, D A (1997) Bone disease in moderate renal failure: cause, nature and prevention. Annu Rev Med 48:167-76
Nakagawa, Y (1997) Properties and function of nephrocalcin: mechanism of kidney stone inhibition or promotion. Keio J Med 46:1-9
Bushinsky, D A; Grynpas, M D; Nilsson, E L et al. (1995) Stone formation in genetic hypercalciuric rats. Kidney Int 48:1705-13
Worcester, E M; Fellner, S K; Nakagawa, Y et al. (1994) Effect of renal transplantation on serum oxalate and urinary oxalate excretion. Nephron 67:414-8
Mustafi, D; Nakagawa, Y (1994) Characterization of calcium-binding sites in the kidney stone inhibitor glycoprotein nephrocalcin with vanadyl ions: electron paramagnetic resonance and electron nuclear double resonance spectroscopy. Proc Natl Acad Sci U S A 91:11323-7
Bushinsky, D A; Kim, M; Sessler, N E et al. (1994) Increased urinary saturation and kidney calcium content in genetic hypercalciuric rats. Kidney Int 45:58-65
Bushinsky, D A; Wolbach, W; Sessler, N E et al. (1993) Physicochemical effects of acidosis on bone calcium flux and surface ion composition. J Bone Miner Res 8:93-102
Sprague, S M; Krieger, N S; Bushinsky, D A (1993) Aluminum inhibits bone nodule formation and calcification in vitro. Am J Physiol 264:F882-90
Kim, M; Sessler, N E; Tembe, V et al. (1993) Response of genetic hypercalciuric rats to a low calcium diet. Kidney Int 43:189-96

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