The intellectual integration of the various sections into a coherent, yet individualistic, scientific research program is realized by our carefully selected set of major scientific themes and rely heavily on and utilize the laboratory to model and simulate clinical and clinico-physiopathologic problems and, through such laboratory efforts, to better understand and quantitate the pathophysiological effects of radiation on human malignant disease and normal tissues. The major research themes for the Radiation Oncology Clinical Investigative Program are: PREDICTIVE BIOCHEMICAL ASSAY(S) for normal organs and tissues and INNOVATIVE CLINICAL TRIALS for studying unique and unorthodox fractionation schema, new radiosensitizers, radio-protectors and chemotherapy. The radiation Biology and Biophysics Program has their focus on TUMOR HETEROGENEITY and tumor physiology, in in vivo (spheroids) and in vivo systems (nude mice) and RADIOBIOLOGICAL and CHEMOTHERAPEUTIC RESPONSES of human tumors in the above models. The Medical Physics Program features BONE AND HIGH-Z TRANSITION ZONE DOSIMETRY, for photons and neutrons and measured NEUTRON SPECTRA for national clinically-based fast neutron radiotherapy effort. Through the design of """"""""cluster"""""""" groups, laboratory ideas are developed into institutional Phase I/II studies. If successful, these trials are integrated into Phase III national cooperative group studies in which the faculty play a leadership role.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA011051-19
Application #
3092543
Study Section
Clinical Cancer Program Project Review Committee (CCP)
Project Start
1977-07-01
Project End
1991-02-28
Budget Start
1989-03-10
Budget End
1990-02-28
Support Year
19
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Rochester
Department
Type
School of Medicine & Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
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Ding, Ivan; Liu, Weimin; Sun, Jianzhong et al. (2003) FGF1 and VEGF mediated angiogenesis in KHT tumor-bearing mice. Adv Exp Med Biol 530:603-9
Liang, Li; Hu, Dongping; Liu, Weimin et al. (2003) Celecoxib reduces skin damage after radiation: selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary tumor. Am J Clin Oncol 26:S114-21
Williams, Jacqueline; Chen, Yuhchyau; Rubin, Philip et al. (2003) The biological basis of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol 13:182-8
Chen, Yuhchyau; Williams, Jacqueline; Ding, Ivan et al. (2002) Radiation pneumonitis and early circulatory cytokine markers. Semin Radiat Oncol 12:26-33

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