The objective of this study is to determine whether fast neutron teletherapy has any advantage over conventional photon teletherapy in the treatment of cancers in humans. The basis of a potential advantage is that hypoxic tumor cells respond better to high LET radiations than conventional photon radiations. Therefore, in those cancers containing even small (1%) components of hypoxic cells, a potential cause of tumor persistence after conventional photon radiation therapy can be reduced or eliminated. The objective of the physics component is to deliver a controlled quantitated beam of fast neutrons coupled with methods of patient handling alignment and treatment planning such that a valid evaluation of fast neutrons as a treatment modality may be expedited. The radiation oncology goals are to study tissue tolerance and tumor response to patterns of treatment and initiate cooperative trials with other fast neutron beam therapy centers.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
3P01CA012441-12S1
Application #
3092557
Study Section
Clinical Cancer Program Project Review Committee (CCP)
Project Start
1979-03-01
Project End
1989-02-28
Budget Start
1984-03-01
Budget End
1989-02-28
Support Year
12
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195