Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA013526-13
Application #
4690407
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Mayer, D; Natsumeda, Y; Ikegami, T et al. (1990) Expression of key enzymes of purine and pyrimidine metabolism in a hepatocyte-derived cell line at different phases of the growth cycle. J Cancer Res Clin Oncol 116:251-8
Grunicke, H H; Yamada, Y; Natsumeda, Y et al. (1989) Histone acetyltransferase activity in rat hepatomas. J Cancer Res Clin Oncol 115:435-8
Weber, G; Jayaram, H N; Lapis, E et al. (1988) Enzyme-pattern-targeted chemotherapy with tiazofurin and allopurinol in human leukemia. Adv Enzyme Regul 27:405-33
Yamada, Y; Natsumeda, Y; Weber, G (1988) Action of the active metabolites of tiazofurin and ribavirin on purified IMP dehydrogenase. Biochemistry 27:2193-6
Pillwein, K; Reardon, M A; Jayaram, H N et al. (1988) Insulin regulatory effects on purine- and pyrimidine metabolism in alloxan diabetic rat liver. Padiatr Padol 23:135-44
Snell, K; Natsumeda, Y; Eble, J N et al. (1988) Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma. Br J Cancer 57:87-90
Natsumeda, Y; Ikegami, T; Murayama, K et al. (1988) De novo guanylate synthesis in the commitment to replication in hepatoma 3924A cells. Cancer Res 48:507-11
Prajda, N; Natsumeda, Y; Ikegami, T et al. (1988) Enzymic programs of rat bone marrow and the impact of acivicin and tiazofurin. Biochem Pharmacol 37:875-80
Hashimoto, Y; Shiotani, T; Eble, J N et al. (1988) Increased thymidylate synthase (EC 2.1.1.45) activity in normal and neoplastic proliferation. Cancer Biochem Biophys 10:1-10
Snell, K; Natsumeda, Y; Weber, G (1987) The modulation of serine metabolism in hepatoma 3924A during different phases of cellular proliferation in culture. Biochem J 245:609-12

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