This Program Project Grant consists of five Projects and two Cores designed to optimize the development of nuclear magnetic resonance technology for both basic cancer research and clinical applications. Three of the Projects concentrate on developing and utilizing ultra high resolution proton imaging procedures. Two of these follow the evolution of preneoplastic tissue to metastatic hepatocellular carcinoma; one in a chemical carcinogenic model in rats, the other in a viral hepatitis model in woodchucks. The remaining one evaluates the efficacy of NMR examinations for diagnosis of metastatic axillary lymph nodes. The other two Projects use primarily NMR spectroscopic methods to investigate the metabolic and physiological consequences of neoplastic transformation. The studies concern pH regulation in well defined cell lines transformed with oncogenes and the metabolism of a range of isolated arterially- perfused hepatomas. An Instrumental Support core provides the technical support to develop the necessary special purpose NMR probes and imaging surface coils required for these Projects. An Administrative Core provides budgetary control and clerical services for the PPG.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA041078-02
Application #
3093813
Study Section
(SRC)
Project Start
1987-06-05
Project End
1990-05-31
Budget Start
1988-06-01
Budget End
1989-05-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Fox Chase Cancer Center
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
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