The goal of this program is to understand cellular transformation at the molecular level: both the genetic events which induce transformation and the alteration in biochemical events which ensue. There are five component sections: Human Oncogenes (Wigler) focuses on new human oncogenes which have either a novel structure or an interesting pattern of expression in neoplasia. Oncogenesis in Transgenic Mice (Hanahan and Field) utilizes a relatively new technology to explore the multistep nature of carcinogenesis in specific tissues. c-fos Transcriptional Activation (Gilman) explores the molecules which induce fos oncogene expression in response to signal transduction. Tropomyosins and Transformation (Helfman) analyses changes in the expression of the tropomyosin isoforms and their effects on the transformed phenotype. Membrane Signal Transduction (Feramisco and Bar-Sagi) describes the interactions of various second messenger systems related to growth proliferation signals which originate at the cellular membrane. The project brings together five diverse approaches to a common problem.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA046370-01
Application #
3094197
Study Section
Cancer Special Program Advisory Committee (CAK)
Project Start
1988-03-01
Project End
1993-02-28
Budget Start
1988-03-01
Budget End
1989-02-28
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Cold Spring Harbor Laboratory
Department
Type
DUNS #
065968786
City
Cold Spring Harbor
State
NY
Country
United States
Zip Code
11724
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