Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA059351-04
Application #
2099940
Study Section
Special Emphasis Panel (SRC (66))
Project Start
1992-09-30
Project End
1997-09-29
Budget Start
1995-09-30
Budget End
1997-09-29
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146
Simpson, S J; De Jong, Y P; Shah, S A et al. (1998) Consequences of Fas-ligand and perforin expression by colon T cells in a mouse model of inflammatory bowel disease. Gastroenterology 115:849-55
Cepero, E; Hnatyszyn, H J; Kraus, G et al. (1998) Potent inhibition of CTLA-4 expression by an anti-CTLA-4 ribozyme. Biochem Biophys Res Commun 247:838-43
Heike, Y; Takahashi, M; Ohira, T et al. (1997) Genetic immunotherapy by intrapleural, intraperitoneal and subcutaneous injection of IL-2 gene-modified Lewis lung carcinoma cells. Int J Cancer 73:844-9
Lee, R K; Spielman, J; Zhao, D Y et al. (1996) Perforin, Fas ligand, and tumor necrosis factor are the major cytotoxic molecules used by lymphokine-activated killer cells. J Immunol 157:1919-25
Liu, B; Podack, E R; Allison, J P et al. (1996) Generation of primary tumor-specific CTL in vitro to immunogenic and poorly immunogenic mouse tumors. J Immunol 156:1117-25
Rukavina, D; Balen-Marunic, S; Rubesa, G et al. (1996) Perforin expression in peripheral blood lymphocytes in rejecting and tolerant kidney transplant recipients. Transplantation 61:285-91
Nishio, M; Spielman, J; Lee, R K et al. (1996) CD80 (B7.1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis. J Immunol 157:4347-53
Nishio, M; Podack, E R (1996) Rapid induction of tumor necrosis factor cytotoxicity in naive splenic T cells by simultaneous CD80 (B7.1) and CD54 (ICAM-1) co-stimulation. Eur J Immunol 26:2160-4
Podack, E R (1995) Perforin, killer cells and gene transfer immunotherapy for cancer. Curr Top Microbiol Immunol 198:121-30
Podack, E R (1995) Functional significance of two cytolytic pathways of cytotoxic T lymphocytes. J Leukoc Biol 57:548-52

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