Abstract

The primary purpose of the Structural Core is to help elucidate structure/function relationships of the various molecular complexes as described in the respective studies in the Program Project. The Core will provide tools such as NMR, X-ray crystallography, surface plasmon resonance, microcalorimetry, and molecular modeling/ computational chemistry to determine structural relationships among the described antibodies and receptors and how they might recognize their specific ligand.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA089480-01A2
Application #
6598278
Study Section
Subcommittee E - Prevention &Control (NCI)
Project Start
2002-05-13
Project End
2006-04-30
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Murali, Ramachandran; Greene, Mark I (2012) Structure based antibody-like peptidomimetics. Pharmaceuticals (Basel) 5:209-35
Ponde, Datta E; Su, ZiFen; Berezov, Alan et al. (2011) Development of anti-EGF receptor peptidomimetics (AERP) as tumor imaging agent. Bioorg Med Chem Lett 21:2550-3
Monzavi-Karbassi, Behjatolah; Hine, R Jean; Stanley, Joseph S et al. (2010) Fructose as a carbon source induces an aggressive phenotype in MDA-MB-468 breast tumor cells. Int J Oncol 37:615-22
Zhang, Tianqian; Herlyn, Dorothee (2009) Combination of active specific immunotherapy or adoptive antibody or lymphocyte immunotherapy with chemotherapy in the treatment of cancer. Cancer Immunol Immunother 58:475-92
Cai, Z; Zhang, G; Zhou, Z et al. (2008) Differential binding patterns of monoclonal antibody 2C4 to the ErbB3-p185her2/neu and the EGFR-p185her2/neu complexes. Oncogene 27:3870-4
Wondimu, Assefa; Zhang, Tianqian; Kieber-Emmons, Thomas et al. (2008) Peptides mimicking GD2 ganglioside elicit cellular, humoral and tumor-protective immune responses in mice. Cancer Immunol Immunother 57:1079-89
Monzavi-Karbassi, Behjatolah; Stanley, J Steven; Hennings, Leah et al. (2007) Chondroitin sulfate glycosaminoglycans as major P-selectin ligands on metastatic breast cancer cell lines. Int J Cancer 120:1179-91
Ko, Eric; Luo, Wei; Peng, Liaomin et al. (2007) Mouse dendritic-endothelial cell hybrids and 4-1BB costimulation elicit antitumor effects mediated by broad antiangiogenic immunity. Cancer Res 67:7875-84
Zhang, Hongtao; Berezov, Alan; Wang, Qiang et al. (2007) ErbB receptors: from oncogenes to targeted cancer therapies. J Clin Invest 117:2051-8
Whitehead, Tracy L; Holley, Andy W; Korourian, Soheila et al. (2007) (1)H nuclear magnetic resonance metabolomic analysis of mammary tumors from lean and obese Zucker rats exposed to 7,12-dimethylbenz[a]anthracene. Int J Mol Med 20:573-80

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